Mark B Gerstein
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Explore the profile of Mark B Gerstein including associated specialties, affiliations and a list of published articles.
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170
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18390
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Recent Articles
1.
Lee S, McAfee J, Lee J, Gomez A, Ledford A, Clarke D, et al.
Cell
. 2025 Jan;
188(5):1409-1424.e21.
PMID: 39848247
A meta-genome-wide association study across eight psychiatric disorders has highlighted the genetic architecture of pleiotropy in major psychiatric disorders. However, mechanisms underlying pleiotropic effects of the associated variants remain to...
2.
Li C, Bonder M, Syed S, Jensen M, Gerstein M, Zody M, et al.
Genome Res
. 2024 Dec;
34(12):2304-2318.
PMID: 39638559
The human genome is packaged within a three-dimensional (3D) nucleus and organized into structural units known as compartments, topologically associating domains (TADs), and loops. TAD boundaries, separating adjacent TADs, have...
3.
Lee H, Emani P, Gerstein M
J Chem Inf Model
. 2024 Nov;
64(23):8684-8704.
PMID: 39576762
The accurate screening of candidate drug ligands against target proteins through computational approaches is of prime interest to drug development efforts. Such virtual screening depends in part on methods to...
4.
Zhang X, Anderson K, Dong H, Chopra S, Dhamala E, Emani P, et al.
Nat Neurosci
. 2024 Nov;
28(1):150-160.
PMID: 39572742
The functional properties of the human brain arise, in part, from the vast assortment of cell types that pattern the cerebral cortex. The cortical sheet can be broadly divided into...
5.
Cameron C, Seager S, Sigworth F, Tagare H, Gerstein M
Commun Biol
. 2024 Nov;
7(1):1421.
PMID: 39482410
Cryo-EM particle identification from micrographs ("picking") is challenging due to the low signal-to-noise ratio and lack of ground truth for particle locations. State-of-the-art computational algorithms ("pickers") identify different particle sets,...
6.
Frank M, Ni P, Jensen M, Gerstein M
Proc Natl Acad Sci U S A
. 2024 Aug;
121(33):e2320510121.
PMID: 39110734
Protein phase transitions (PPTs) from the soluble state to a dense liquid phase (forming droplets via liquid-liquid phase separation) or to solid aggregates (such as amyloids) play key roles in...
7.
Tang X, Tran A, Tan J, Gerstein M
Bioinformatics
. 2024 Jun;
40(Suppl 1):i357-i368.
PMID: 38940177
Motivation: The current paradigm of deep learning models for the joint representation of molecules and text primarily relies on 1D or 2D molecular formats, neglecting significant 3D structural information that...
8.
Tang X, Qian B, Gao R, Chen J, Chen X, Gerstein M
Bioinformatics
. 2024 Jun;
40(Suppl 1):i266-i276.
PMID: 38940140
Summary: Pretrained large language models (LLMs) have significantly improved code generation. As these models scale up, there is an increasing need for the output to handle more intricate tasks and...
9.
Warrell J, Salichos L, Gancz M, Gerstein M
J R Soc Interface
. 2024 Mar;
21(212):20230647.
PMID: 38503341
Cultural processes of change bear many resemblances to biological evolution. The underlying units of non-biological evolution have, however, remained elusive, especially in the domain of music. Here, we introduce a...
10.
Emani P, Geradi M, Gursoy G, Grasty M, Miranker A, Gerstein M
Genome Res
. 2023 Dec;
33(12):2156-2173.
PMID: 38097386
Single nucleotide polymorphisms (SNPs) from omics data create a reidentification risk for individuals and their relatives. Although the ability of thousands of SNPs (especially rare ones) to identify individuals has...