Jonathan W Engle
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Explore the profile of Jonathan W Engle including associated specialties, affiliations and a list of published articles.
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167
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Recent Articles
1.
Huang W, Wang T, Chao F, Yang Q, Mixdorf J, Li L, et al.
Mol Pharm
. 2025 Mar;
PMID: 40059341
Trop2 exhibits significantly elevated expression in numerous solid malignancies, playing a crucial role in tumor advancement, whereas its presence in healthy tissues is minimal. In this study, we investigated Trop2...
2.
Li X, Zhang Y, Mixdorf J, Wu Q, Lee S, Engle J, et al.
J Nucl Med
. 2025 Feb;
PMID: 40015924
CD70 is an emerging biomarker for both solid tumors and hematologic malignancies, highlighting the urgent need for a molecular imaging tracer capable of visualizing CD70 with favorable pharmacokinetics. ABDB6 was...
3.
Huang W, Zhang Y, Xiao X, Yang Q, Mixdorf J, Sun X, et al.
Eur J Nucl Med Mol Imaging
. 2025 Feb;
PMID: 39994021
Purpose: The Trop2-targeting antibody-drug conjugate (ADC) sacituzumab govitecan (Trodelvy) has demonstrated remarkable efficacy in patients with metastatic triple-negative breast cancer (TNBC). ImmunoPET imaging offers a noninvasive method to visualize the...
4.
Huang W, Li L, Zhou Y, Yang Q, Mixdorf J, Barnhart T, et al.
Eur J Nucl Med Mol Imaging
. 2025 Jan;
PMID: 39878898
Purpose: Trophoblast cell-surface antigen 2 (Trop2) is overexpressed in various solid tumors and contributes to tumor progression, while its expression remains low in normal tissues. Trop2-targeting antibody-drug conjugate (ADC), sacituzumab...
5.
Olson A, Olson A, Schrage B, Schrage B, Islam M, Fletcher L, et al.
Angew Chem Int Ed Engl
. 2025 Jan;
:e202423878.
PMID: 39878457
Antimony-119 (Sb) is one of the most attractive Auger-electron emitters identified to date, but it remains practically unexplored for targeted radiotherapy because no chelators have been identified to stably bind...
6.
Gunaratne G, Gallant J, Ott K, Broome P, Celada S, West J, et al.
bioRxiv
. 2025 Jan;
PMID: 39868181
Cancer-associated fibroblasts (CAFs) in the stroma of solid tumors promote an immunosuppressive tumor microenvironment (TME) that drives resistance to therapies. The expression of the protease fibroblast activation protein (FAP) on...
7.
Harr T, Gupta N, Rahar B, Stott K, Medina-Guevara Y, Gari M, et al.
Respir Res
. 2025 Jan;
26(1):34.
PMID: 39844185
Progressive forms of interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF), are deadly disorders lacking non-invasive biomarkers for assessment of early disease activity, which presents a major obstacle in disease...
8.
Siikanen J, Milton S, Bratteby K, Lin W, Engle J, Jussing E, et al.
EJNMMI Radiopharm Chem
. 2025 Jan;
10(1):4.
PMID: 39836306
Background: Beyond the use of conventional short-lived PET radionuclides, there is a growing interest in tracking larger biomolecules and exploring radiotheranostic applications. One promising option for imaging medium-sized molecules and...
9.
Lo Y, Miller A, Brown G, Peaslee G, Engle J, Ellison P
Appl Radiat Isot
. 2025 Jan;
217():111654.
PMID: 39754961
This work reports experimental Ge(d,n)As cross sections producing Arsenic-71 (t = 65.3 h, 28% β), a potentially useful diagnostic radionuclide. Target stacks containing two Ge foils, a Ni monitor foil,...
10.
Barrett K, Mixdorf J, Svedjehed J, Batterton J, Eagleburger J, Yan Y, et al.
Nucl Med Biol
. 2024 Dec;
142-143:108989.
PMID: 39729887
We report DGA extraction chromatography isolation of Mn from isotopically enriched Fe. The method has been studied in semi-automated and automated realizations. The former achieves a decay corrected radiochemical yield...