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Reinier Hernandez

Explore the profile of Reinier Hernandez including associated specialties, affiliations and a list of published articles. Areas
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Articles 70
Citations 1470
Followers 0
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Recent Articles
1.
Gunaratne G, Gallant J, Ott K, Broome P, Celada S, West J, et al.
bioRxiv . 2025 Jan; PMID: 39868181
Cancer-associated fibroblasts (CAFs) in the stroma of solid tumors promote an immunosuppressive tumor microenvironment (TME) that drives resistance to therapies. The expression of the protease fibroblast activation protein (FAP) on...
2.
Harr T, Gupta N, Rahar B, Stott K, Medina-Guevara Y, Gari M, et al.
Respir Res . 2025 Jan; 26(1):34. PMID: 39844185
Progressive forms of interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF), are deadly disorders lacking non-invasive biomarkers for assessment of early disease activity, which presents a major obstacle in disease...
3.
Kerr C, Jin W, Liu P, Grudzinski J, Ferreira C, Rojas H, et al.
bioRxiv . 2025 Jan; PMID: 39763914
Radiopharmaceutical therapy (RPT) enhances tumor response to immune checkpoint inhibitors (ICI) in preclinical models, but the effects of different radioisotopes have not been thoroughly compared. To evaluate mechanisms of response...
4.
Minne R, Luo N, Mork C, Wopat M, Esbona K, Javeri S, et al.
Mol Pharm . 2024 Nov; 21(12):6376-6384. PMID: 39513517
In head and neck squamous cell carcinoma (HNSCC), the mesenchymal epithelial transition (MET) receptor drives cancer growth, proliferation, and metastasis. MET is known to be overexpressed in HNSCC and, therefore,...
5.
Rosenkrans Z, Thickens A, Kink J, Aluicio-Sarduy E, Engle J, Hematti P, et al.
Mol Pharm . 2024 Aug; 21(9):4324-4335. PMID: 39164886
Positron emission tomography (PET) is a powerful tool for investigating the in vivo behavior of drug delivery systems. We aimed to assess the biodistribution of extracellular vesicles (EVs), nanosized vesicles...
6.
Kerr C, Sheehan-Klenk J, Grudzinski J, Adam D, Nguyen T, Ferreira C, et al.
bioRxiv . 2024 Jul; PMID: 39071353
Teaser: This study describes the time course and nature of tumor immunomodulation by radiopharmaceuticals with differing physical properties.
7.
Rosenkrans Z, Erbe A, Clemons N, Feils A, Medina-Guevara Y, Jeffery J, et al.
bioRxiv . 2024 Jun; PMID: 38853889
Objectives: Disialoganglioside 2 (GD2), overexpressed by cancers such as melanoma and neuroblastoma, is a tumor antigen for targeted therapy. The delivery of conventional IgG antibody technologies targeting GD2 is limited...
8.
Gallant J, Hintz H, Gunaratne G, Breneman M, Recchia E, West J, et al.
Cancer Res Commun . 2024 May; 4(6):1481-1494. PMID: 38747612
Significance: The direct elimination of FAP-expressing CAFs disrupts the cross-talk with cancer cells leading to a proinflammatory response and alterations in the immune microenvironment and antitumor immune response.
9.
Muralidhar A, Hernandez R, Morris Z, Rojas H, Idrissou M, Weichert J, et al.
J Immunother Cancer . 2024 Apr; 12(4). PMID: 38663936
Rationale: Androgen deprivation therapy (ADT) is pivotal in treating recurrent prostate cancer and is often combined with external beam radiation therapy (EBRT) for localized disease. However, for metastatic castration-resistant prostate...
10.
Lee H, Bernau K, Harr T, Rosenkrans Z, Kessler G, Stott K, et al.
Sci Adv . 2024 Apr; 10(15):eadj1444. PMID: 38598637
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease resulting in irreversible scarring within the lungs. However, the lack of biomarkers that enable real-time assessment of disease activity remains a...