Jonathan W Bogart
Overview
Explore the profile of Jonathan W Bogart including associated specialties, affiliations and a list of published articles.
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13
Citations
203
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Recent Articles
1.
Landwehr G, Bogart J, Magalhaes C, Hammarlund E, Karim A, Jewett M
Nat Commun
. 2025 Jan;
16(1):865.
PMID: 39833164
Enzyme engineering is limited by the challenge of rapidly generating and using large datasets of sequence-function relationships for predictive design. To address this challenge, we develop a machine learning (ML)-guided...
2.
Rasor B, Vogeli B, Landwehr G, Bogart J, Karim A, Jewett M
Curr Opin Biotechnol
. 2021 Jan;
69:136-144.
PMID: 33453438
Industrial biotechnology is an attractive approach to address the need for low-cost fuels and products from sustainable resources. Unfortunately, cells impose inherent limitations on the effective synthesis and release of...
3.
Bogart J, Cabezas M, Vogeli B, Wong D, Karim A, Jewett M
Chembiochem
. 2020 Aug;
22(1):84-91.
PMID: 32783358
Natural products and secondary metabolites comprise an indispensable resource from living organisms that have transformed areas of medicine, agriculture, and biotechnology. Recent advances in high-throughput DNA sequencing and computational analysis...
4.
Bogart J, Kramer N, Turlik A, Bleich R, Catlin D, Schroeder F, et al.
J Am Chem Soc
. 2020 Jul;
142(30):13170-13179.
PMID: 32609512
Thiopeptides are a broad class of macrocyclic, heavily modified peptide natural products that are unified by the presence of a substituted, nitrogen-containing heterocycle core. Early work indicated that this core...
5.
Puhl A, Bogart J, Haberman V, Larson J, Godoy A, Norris-Drouin J, et al.
ACS Chem Biol
. 2020 May;
15(6):1505-1516.
PMID: 32383857
Calcium and integrin binding protein 1 (CIB1) is an EF-hand-containing, small intracellular protein that has recently been implicated in cancer cell survival and proliferation. In particular, CIB1 depletion significantly impairs...
6.
Bogart J, Bowers A
Org Biomol Chem
. 2019 Mar;
17(15):3653-3669.
PMID: 30849157
α,β-Dehydroamino acids (dhAAs) are noncanonical amino acids that are found in a wide array of natural products and can be easily installed into peptides and proteins. dhAAs exhibit remarkable synthetic...
7.
Bogart J, Bowers A
J Am Chem Soc
. 2019 Jan;
141(5):1842-1846.
PMID: 30653303
Thiopeptide pyridine synthases catalyze a multistep reaction involving a unique and nonspontaneous intramolecular aza-[4 + 2] cycloaddition between two dehydroalanines to forge a trisubstituted pyridine core. We discovered that the...
8.
Teske K, Bogart J, Arnold L
Bioorg Med Chem Lett
. 2017 Dec;
28(3):351-354.
PMID: 29287957
The vitamin D receptor is a nuclear hormone receptor that regulates cell proliferation, cell differentiation and calcium homeostasis. The receptor is endogenously activated by 1,25-dihydroxyvitamin D, which induces transcription of...
9.
Gober J, Ghodge S, Bogart J, Wever W, Watkins R, Brustad E, et al.
ACS Chem Biol
. 2017 May;
12(7):1726-1731.
PMID: 28535034
Thiopeptides are a growing class of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products. Many biosynthetic enzymes for RiPPs, especially thiopeptides, are promiscuous and can accept a wide range...
10.
Wever W, Bogart J, Bowers A
J Am Chem Soc
. 2016 Aug;
138(41):13461-13464.
PMID: 27575591
Thiopeptides are structurally complex, bioactive natural products derived from ribosomally synthesized and post-translationally modified peptides. A remarkable set of enzymes were recently revealed to catalyze the formation of the core...