Nicholas R Silvaggi
Overview
Explore the profile of Nicholas R Silvaggi including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
551
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Recent Articles
1.
Zhu X, Wang R, Siitonen V, Vuksanovic N, Silvaggi N, Melancon Iii C, et al.
PLoS One
. 2024 Aug;
19(8):e0308684.
PMID: 39121077
The biosynthetic pathway of actinorhodin in Streptomyces coelicolor A3(2) has been studied for decades as a model system of type II polyketide biosynthesis. The actinorhodin biosynthetic gene cluster includes a...
2.
Vuksanovic N, Melkonian T, Serrano D, Schwabacher A, Silvaggi N
Biochemistry
. 2023 Oct;
62(21):3105-3115.
PMID: 37890134
MppQ is an enzyme of unknown function from (ShMppQ) that operates in the biosynthesis of the nonproteinogenic amino acid L-enduracididine (L-End). Since L-End is a component of several peptides showing...
3.
Melkonian T, Vuksanovic N, Silvaggi N
Methods Enzymol
. 2023 May;
685:493-529.
PMID: 37245913
The pyridoxal-5'-phosphate-dependent l-Arg oxidases are unusual in that they are able to catalyze 4-electron oxidations of arginine using only the PLP cofactor. No metals or other accessory cosubstrates are involved;...
4.
Johnston N, Samuels T, Goetz C, Arnold L, Smith B, Seabloom D, et al.
Laryngoscope
. 2022 Jun;
133 Suppl 1:S1-S11.
PMID: 35678265
Objective: More than 20% of the US population suffers from laryngopharyngeal reflux. Although dietary/lifestyle modifications and alginates provide benefit to some, there is no gold standard medical therapy. Increasing evidence...
5.
Turner L, Nielsen A, Lin L, Campedelli A, Silvaggi N, Chen J, et al.
ACS Med Chem Lett
. 2021 Aug;
12(8):1318-1324.
PMID: 34413962
Botulinum neurotoxins (BoNTs) are extremely toxic and have been deemed a Tier 1 potential bioterrorism agent. The most potent and persistent of the BoNTs is the "A" serotype, with strategies...
6.
Virdi R, Bavisotto R, Hopper N, Vuksanovic N, Melkonian T, Silvaggi N, et al.
SLAS Discov
. 2020 Sep;
25(10):1162-1170.
PMID: 32981460
Small molecules that bind the SARS-CoV-2 nonstructural protein 3 Mac1 domain in place of ADP-ribose could be useful as molecular probes or scaffolds for COVID-19 antiviral drug discovery because Mac1...
7.
Roman J, Melkonian T, Silvaggi N, Moran G
Biochemistry
. 2020 Aug;
59(35):3284.
PMID: 32847354
No abstract available.
8.
Vuksanovic N, Zhu X, Serrano D, Siitonen V, Metsa-Ketela M, Melancon 3rd C, et al.
Acta Crystallogr F Struct Biol Commun
. 2020 Aug;
76(Pt 8):372-383.
PMID: 32744249
Proteins belonging to the NTF2-like superfamily are present in the biosynthetic pathways of numerous polyketide natural products, such as anthracyclins and benzoisochromanequinones. Some have been found to be bona fide...
9.
Virdi R, Bavisotto R, Hopper N, Vuksanovic N, Melkonian T, Silvaggi N, et al.
bioRxiv
. 2020 Jul;
PMID: 32676591
Small molecules that bind the SARS-CoV-2 non-structural protein 3 Mac1 domain in place of ADP-ribose could be useful as molecular probes or scaffolds for COVID-19 antiviral drug discovery because Mac1...
10.
Frick D, Virdi R, Vuksanovic N, Dahal N, Silvaggi N
Biochemistry
. 2020 Jun;
59(28):2608-2615.
PMID: 32578982
The virus that causes COVID-19, SARS-CoV-2, has a large RNA genome that encodes numerous proteins that might be targets for antiviral drugs. Some of these proteins, such as the RNA-dependent...