Jonathan Shupe
Overview
Explore the profile of Jonathan Shupe including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
985
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0
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Recent Articles
1.
Sweet R, Christensen S, Harris M, Shupe J, Sutherland J, Shlomchik M
Autoimmunity
. 2010 Apr;
43(8):607-18.
PMID: 20370572
The AM14 rheumatoid factor (RF) transgenic (Tg) mouse has been valuable for studying how self-reactive B cells are regulated beyond central tolerance, because they remain ignorant in normal mice. AM14...
2.
Nickerson K, Christensen S, Shupe J, Kashgarian M, Kim D, Elkon K, et al.
J Immunol
. 2010 Jan;
184(4):1840-8.
PMID: 20089701
Systemic lupus erythematosus is characterized by the production of autoantibodies against nucleic acid-associated Ags. We previously found that Tlr7 was required for anti-Sm and Tlr9 for anti-chromatin autoantibodies. Yet, although...
3.
Salazar J, Duhnam-Ems S, La Vake C, Cruz A, Moore M, Caimano M, et al.
PLoS Pathog
. 2009 May;
5(5):e1000444.
PMID: 19461888
It is widely believed that innate immune responses to Borrelia burgdorferi (Bb) are primarily triggered by the spirochete's outer membrane lipoproteins signaling through cell surface TLR1/2. We recently challenged this...
4.
Ahuja A, Shupe J, Dunn R, Kashgarian M, Kehry M, Shlomchik M
J Immunol
. 2007 Aug;
179(5):3351-61.
PMID: 17709552
In mice, genetic deletion of B cells strongly suppresses systemic autoimmunity, providing a rationale for depleting B cells to treat autoimmunity. In fact, B cell depletion with rituximab is approved...
5.
Christensen S, Shupe J, Nickerson K, Kashgarian M, Flavell R, Shlomchik M
Immunity
. 2006 Sep;
25(3):417-28.
PMID: 16973389
Antibodies (Abs) to RNA- and DNA-containing autoantigens are characteristic of systemic lupus erythematosus (SLE). We showed previously that Toll-like receptor (TLR) 9, recognizing DNA, is required for the spontaneous generation...