Jonathan R Scheerer
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Explore the profile of Jonathan R Scheerer including associated specialties, affiliations and a list of published articles.
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26
Citations
216
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Recent Articles
1.
Thompson L, Kinsey A, Shahla Z, Scheerer J
J Org Chem
. 2024 Nov;
89(23):17635-17642.
PMID: 39532705
This study describes a general method for the preparation of 1,4-oxazin-2-one intermediates from acetylene dicarboxylate and β-amino alcohol precursors. Oxazinones prepared in this manner were employed in a tandem cycloaddition/cycloreversion...
2.
Lehman V, Ma Y, Scheerer J
J Org Chem
. 2024 Jul;
89(15):11078-11082.
PMID: 39014934
This study describes the synthesis of the 4-azafluorenone core in a single operation using readily available starting materials. Condensation of an amidrazone with ninhydrin intercepts an intermediate 1,2,4-triazine derivative, which...
3.
Scheerer J, Leeth E, Sprow J
Synthesis (Stuttg)
. 2023 Sep;
55(15):2319-2324.
PMID: 37691879
A new method to prepare 1,4-oxazinone intermediates was developed based on aza-conjugate addition of β-amino alcohols to electron-deficient alkyne precursors. A tandem intramolecular cycloaddition/cycloreversion reaction sequence was evaluated, leading to...
4.
Pudner G, Camp I, Scheerer J
J Org Chem
. 2022 May;
87(12):8213-8222.
PMID: 35613467
This study investigates a synthetic sequence for the preparation of 1,2-diketone products. The sequence avoids oxidative conditions and instead employs reliable transformations including the Horner-Wadsworth-Emmons and addition of Grignard reagents...
5.
Carrillo Vallejo N, Scheerer J
J Org Chem
. 2021 Apr;
86(8):5863-5869.
PMID: 33797249
This study reveals a new method for the preparation of 1,4-oxazinone derivatives by Staudinger reductive cyclization of functionalized vinyl azide precursors. The resulting oxazinone derivatives prepared in this manner were...
6.
Angello N, Wiley R, Abelt C, Scheerer J
Molecules
. 2020 Jul;
25(15).
PMID: 32722081
A new extension for the 'one pot' construction of diverse 1-azafluorene derivatives featuring a Diels-Alder/retro-Diels-Alder cycloaddition is reported. Conditions were also determined for oxidation to the derived azafluorenones. The spectrophotometric...
7.
Maisto S, Leersnyder A, Pudner G, Scheerer J
J Org Chem
. 2020 Jul;
85(14):9264-9271.
PMID: 32602717
This study reveals an alternative sequence for the synthesis of compounds that contain the pyrrolodiketopiperazine structural motif. Starting with a diketopiperazine precursor, a mild aldol condensation precedes pyrrole annulation and...
8.
Smith Z, Wang X, Scheerer J, Martens J, Berden G, Oomens J, et al.
J Am Soc Mass Spectrom
. 2019 Jun;
30(9):1565-1577.
PMID: 31183839
Infrared multiple photon dissociation action spectroscopy was performed on the AlaOrn b and AlaAlaOrn b fragment ions from ornithine-containing tetrapeptides. Infrared spectra were obtained in the fingerprint region (1000-2000 cm)...
9.
Angello N, Wiley R, Elmore T, Perry R, Scheerer J
Org Lett
. 2018 Aug;
20(17):5203-5207.
PMID: 30095269
A new domino reaction sequence for the construction of 2-pyridone structures is reported. The reaction sequence begins with diacetyldiketopiperazine and proceeds via aldol condensation, alkene isomerization, and intramolecular Diels-Alder cycloaddition....
10.
Williamson J, Smith E, Scheerer J
Synlett
. 2018 Feb;
28(10):1170-1172.
PMID: 29398786
A domino reaction sequence has been evaluated that begins with union of novel dihydrooxazinone precursors with 2-alkynyl-substituted benzaldehyde components through aldol condensation. Ensuing operations, including alkene isomerization, Diels-Alder, and retrograde...