Kaila A Margrey
Overview
Explore the profile of Kaila A Margrey including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
9
Citations
338
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Kattar S, Gulati A, Margrey K, Keylor M, Ardolino M, Yan X, et al.
J Med Chem
. 2023 Oct;
66(21):14912-14927.
PMID: 37861679
Genetic mutation of the leucine-rich repeat kinase 2 (LRRK2) protein has been associated with Parkinson's disease (PD), a disabling and progressive neurodegenerative disorder that is devoid of efficacious disease-modifying therapies....
2.
Keylor M, Gulati A, Kattar S, Johnson R, Chau R, Margrey K, et al.
J Med Chem
. 2021 Dec;
65(1):838-856.
PMID: 34967623
The leucine-rich repeat kinase 2 (LRRK2) protein has been genetically and functionally linked to Parkinson's disease (PD), a disabling and progressive neurodegenerative disorder whose current therapies are limited in scope...
3.
Margrey K, Czaplyski W, Nicewicz D, Alexanian E
J Am Chem Soc
. 2018 Mar;
140(12):4213-4217.
PMID: 29522330
Synthetic transformations that functionalize unactivated aliphatic C-H bonds in an intermolecular fashion offer unique strategies for the synthesis and late-stage derivatization of complex molecules. Herein we report a general approach...
4.
Margrey K, Levens A, Nicewicz D
Angew Chem Int Ed Engl
. 2017 Oct;
56(49):15644-15648.
PMID: 29063646
The direct catalytic C-H amination of arenes is a powerful synthetic strategy with useful applications in pharmaceuticals, agrochemicals, and materials chemistry. Despite the advances in catalytic C-H functionalization, the use...
5.
Margrey K, McManus J, Bonazzi S, Zecri F, Nicewicz D
J Am Chem Soc
. 2017 Jul;
139(32):11288-11299.
PMID: 28718642
Direct C-H functionalization of aromatic compounds is a useful synthetic strategy that has garnered much attention because of its application to pharmaceuticals, agrochemicals, and late-stage functionalization reactions on complex molecules....
6.
Margrey K, Nicewicz D
Acc Chem Res
. 2016 Sep;
49(9):1997-2006.
PMID: 27588818
The development of methods for anti-Markovnikov alkene hydrofunctionalization has been a focal point of catalysis research for several decades. The vast majority of work on the control of regioselectivity for...
7.
Romero N, Margrey K, Tay N, Nicewicz D
Science
. 2015 Sep;
349(6254):1326-30.
PMID: 26383949
Over the past several decades, organometallic cross-coupling chemistry has developed into one of the most reliable approaches to assemble complex aromatic compounds from preoxidized starting materials. More recently, transition metal-catalyzed...
8.
Margrey K, Hazzard A, Scheerer J
Org Lett
. 2014 Jan;
16(3):904-7.
PMID: 24476062
A general strategy for the conversion of [2.2.2]-diazabicyclic alkene structures to 2-pyridone aromatic heterocyclic products is reported. The reaction sequence starts from 2,5-diketopiperazine (DKP) derivatives, is compatible with both aromatic...
9.
Margrey K, Chinn A, Laws S, Pike R, Scheerer J
Org Lett
. 2012 May;
14(10):2458-61.
PMID: 22571782
A domino reaction sequence involving aldol condensation, alkene isomerization, and intramolecular hetero-Diels-Alder cycloaddition for the synthesis of [2.2.2]-diazabicyclic structures is reported. Excellent diastereofacial control during the cycloaddition is enforced with...