Jonathan R Chubb
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Explore the profile of Jonathan R Chubb including associated specialties, affiliations and a list of published articles.
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1945
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Recent Articles
11.
Deathridge J, Antolovic V, Parsons M, Chubb J
Development
. 2019 May;
146(12).
PMID: 31064783
Stimulation of the ERK/MAPK pathway is required for the exit from pluripotency and onset of differentiation in mouse embryonic stem cells (ESCs). The dynamic behaviour of ERK activity in individual...
12.
Miermont A, Antolovic V, Lenn T, Nichols J, Millward L, Chubb J
Development
. 2019 Apr;
146(12).
PMID: 30975700
Embryonic development involves extensive and often rapid cell proliferation. An unavoidable side effect of cell proliferation is DNA damage. The consequences of spontaneous DNA damage during development are not clear....
13.
Antolovic V, Lenn T, Miermont A, Chubb J
Development
. 2019 Mar;
146(12).
PMID: 30890571
The generation of multiple fates from a uniform cell population via self-organisation is a recurring feature in development and regeneration. However, for most self-organising systems, we have little understanding of...
14.
Paschke P, Knecht D, Williams T, Thomason P, Insall R, Chubb J, et al.
J Vis Exp
. 2019 Feb;
(143).
PMID: 30735174
Dictyostelium discoideum is an intriguing model organism for the study of cell differentiation processes during development, cell signaling, and other important cellular biology questions. The technologies available to genetically manipulate...
15.
Nichols J, Paschke P, Peak-Chew S, Williams T, Tweedy L, Skehel M, et al.
Dev Cell
. 2019 Jan;
48(4):491-505.e9.
PMID: 30612939
Signaling from chemoattractant receptors activates the cytoskeleton of crawling cells for chemotaxis. We show using phosphoproteomics that different chemoattractants cause phosphorylation of the same core set of around 80 proteins...
16.
Tunnacliffe E, Corrigan A, Chubb J
Proc Natl Acad Sci U S A
. 2018 Aug;
115(33):8364-8369.
PMID: 30061408
During the evolution of gene families, functional diversification of proteins often follows gene duplication. However, many gene families expand while preserving protein sequence. Why do cells maintain multiple copies of...
17.
Paschke P, Knecht D, Silale A, Traynor D, Williams T, Thomason P, et al.
PLoS One
. 2018 May;
13(5):e0196809.
PMID: 29847546
Dictyostelium has a mature technology for molecular-genetic manipulation based around transfection using several different selectable markers, marker re-cycling, homologous recombination and insertional mutagenesis, all supported by a well-annotated genome. However...
18.
Chubb J
Wiley Interdiscip Rev Dev Biol
. 2017 Jul;
6(6).
PMID: 28719044
The prevailing emphasis in developmental biology since the expansion of the molecular biology age has been that developmental decisions are instructive. A cell differentiates to become a specific cell type...
19.
Antolovic V, Miermont A, Corrigan A, Chubb J
Curr Biol
. 2017 Jun;
27(12):1811-1817.e3.
PMID: 28602650
Gene expression levels vary greatly within similar cells, even within clonal cell populations [1]. These spontaneous expression differences underlie cell fate diversity in both differentiation and disease [2]. The mechanisms...
20.
Meyer E, Carss K, Rankin J, Nichols J, Grozeva D, Joseph A, et al.
Nat Genet
. 2017 May;
49(6):969.
PMID: 28546572
No abstract available.