Peggy Paschke
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Explore the profile of Peggy Paschke including associated specialties, affiliations and a list of published articles.
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19
Citations
228
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Recent Articles
1.
Buracco S, Doring H, Engelbart S, Singh S, Paschke P, Whitelaw J, et al.
Curr Biol
. 2024 Sep;
34(19):4436-4451.e9.
PMID: 39332399
Cell migration requires the constant modification of cellular shape by reorganization of the actin cytoskeleton. Fine-tuning of this process is critical to ensure new actin filaments are formed only at...
2.
Lutton J, Coker H, Paschke P, Munn C, King J, Bretschneider T, et al.
Curr Biol
. 2023 Jun;
33(15):3083-3096.e6.
PMID: 37379843
Macropinocytosis is a conserved endocytic process by which cells engulf droplets of medium into micron-sized vesicles. We use light-sheet microscopy to define an underlying set of principles by which macropinocytic...
3.
Koessinger D, Novo D, Koessinger A, Campos A, Peters J, Dutton L, et al.
Neurooncol Adv
. 2023 Jun;
5(1):vdad067.
PMID: 37334166
Background: Infiltration of glioblastoma (GBM) throughout the brain leads to its inevitable recurrence following standard-of-care treatments, such as surgical resection, chemo-, and radiotherapy. A deeper understanding of the mechanisms invoked...
4.
Singh S, Paschke P, Tweedy L, Insall R
Front Mol Biosci
. 2022 Sep;
9:965921.
PMID: 36106016
Cell polarity and cell migration both depend on pseudopodia and lamellipodia formation. These are regulated by coordinated signaling acting through G-protein coupled receptors and kinases such as PKB/AKT and SGK,...
5.
Kay R, Lutton J, Coker H, Paschke P, King J, Bretschneider T
Subcell Biochem
. 2022 Apr;
98:41-59.
PMID: 35378702
Macropinocytosis is a relatively unexplored form of large-scale endocytosis driven by the actin cytoskeleton. Dictyostelium amoebae form macropinosomes from cups extended from the plasma membrane, then digest their contents and...
6.
Insall R, Paschke P, Tweedy L
Trends Cell Biol
. 2022 Mar;
32(7):585-596.
PMID: 35351380
Chemotaxis, where cell movement is steered by chemical gradients, is a widespread and essential way of organising cell behaviour. But where do the instructions come from - who makes gradients,...
7.
Nichols J, Antolovic V, Reich J, Brameyer S, Paschke P, Chubb J
Elife
. 2020 Apr;
9.
PMID: 32255425
Dedifferentiation is a critical response to tissue damage, yet is not well understood, even at a basic phenomenological level. Developing cells undergo highly efficient dedifferentiation, completed by most cells within...
8.
Kay R, Williams T, Manton J, Traynor D, Paschke P
Int J Dev Biol
. 2019 Dec;
63(8-9-10):473-483.
PMID: 31840785
Macropinocytosis is used by a variety of amoebae for feeding on liquid medium. The amoebae project cups and ruffles from their plasma membrane, driven by actin polymerization, and eventually fuse...
9.
Paschke P, Knecht D, Williams T, Thomason P, Insall R, Chubb J, et al.
J Vis Exp
. 2019 Feb;
(143).
PMID: 30735174
Dictyostelium discoideum is an intriguing model organism for the study of cell differentiation processes during development, cell signaling, and other important cellular biology questions. The technologies available to genetically manipulate...
10.
Bloomfield G, Paschke P, Okamoto M, Stevens T, Urushihara H
Proc Natl Acad Sci U S A
. 2019 Jan;
116(6):2187-2192.
PMID: 30670662
Sex promotes the recombination and reassortment of genetic material and is prevalent across eukaryotes, although our knowledge of the molecular details of sexual inheritance is scant in several major lineages....