Jonathan P Richardson
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Explore the profile of Jonathan P Richardson including associated specialties, affiliations and a list of published articles.
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50
Citations
1994
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Recent Articles
1.
Wickramasinghe D, Lyon C, Lee S, Hepworth O, Priest E, Maufrais C, et al.
mBio
. 2024 Jul;
15(8):e0335123.
PMID: 38953356
Importance: Fungal infections are a significant burden to health. Candidalysin is a toxin produced by that damages host tissues, facilitating infection. Previously, we demonstrated that candidalysins exist in the related...
2.
Muller R, Konig A, Groth S, Zarnowski R, Visser C, Handrianz T, et al.
Nat Microbiol
. 2024 Feb;
9(3):669-683.
PMID: 38388771
The opportunistic fungal pathogen Candida albicans damages host cells via its peptide toxin, candidalysin. Before secretion, candidalysin is embedded in a precursor protein, Ece1, which consists of a signal peptide,...
3.
Wu Y, Du S, Bimler L, Mauk K, Lortal L, Kichik N, et al.
Cell Rep
. 2023 Oct;
42(10):113240.
PMID: 37819761
The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer's disease (AD), but the molecular basis of brain anti-Candida immunity remains unknown. We show that C. ...
4.
Zhang J, Chen J, Richardson J, Francis-Newton N, Lai P, Jenkins K, et al.
ACS Pharmacol Transl Sci
. 2022 Sep;
5(9):735-751.
PMID: 36110379
Whereas treatment of allergic diseases such as asthma relies largely on the targeting of dysregulated effector pathways, the conceptually attractive alternative of preventing them by a pharmaceutical, at-source intervention has...
5.
Ponde N, Lortal L, Tsavou A, Hepworth O, Wickramasinghe D, Ho J, et al.
J Biol Chem
. 2022 Aug;
298(10):102419.
PMID: 36037968
Candida albicans (C. albicans) is a dimorphic commensal human fungal pathogen that can cause severe oropharyngeal candidiasis (oral thrush) in susceptible hosts. During invasive infection, C. albicans hyphae invade oral...
6.
Lee S, Kichik N, Hepworth O, Richardson J, Naglik J
Methods Mol Biol
. 2022 Aug;
2542:163-176.
PMID: 36008664
In 2016, the first peptide toxin in any human fungal pathogen was identified. It was discovered in Candida albicans and was named candidalysin. Candidalysin is an amphipathic cationic peptide that...
7.
8.
Richardson J, Brown R, Kichik N, Lee S, Priest E, Mogavero S, et al.
mBio
. 2022 Jan;
13(1):e0351021.
PMID: 35073742
Candidalysin is the first cytolytic peptide toxin identified in any human fungal pathogen. Candidalysin is secreted by Candida albicans and is critical for driving infection and host immune responses in...
9.
Liu J, Willems H, Sansevere E, Allert S, Barker K, Lowes D, et al.
PLoS Pathog
. 2021 Sep;
17(9):e1009884.
PMID: 34506615
Vulvovaginal candidiasis (VVC), caused primarily by the human fungal pathogen Candida albicans, results in significant quality-of-life issues for women worldwide. Candidalysin, a toxin derived from a polypeptide (Ece1p) encoded by...
10.
Blagojevic M, Camilli G, Maxson M, Hube B, Moyes D, Richardson J, et al.
Cell Microbiol
. 2021 Jun;
23(10):e13371.
PMID: 34085369
Candida albicans is a common opportunistic fungal pathogen that causes a wide range of infections from superficial mucosal to hematogenously disseminated candidiasis. The hyphal form plays an important role in...