Julian R Naglik
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Explore the profile of Julian R Naglik including associated specialties, affiliations and a list of published articles.
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97
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4832
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Recent Articles
1.
Dickenson R, Pellon A, Ponde N, Hepworth O, Daniels Gatward L, Naglik J, et al.
Virulence
. 2024 Dec;
15(1):2435374.
PMID: 39635778
is a fungal pathobiont colonizing mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, invades mucosal tissues activating EGFR-MAPK signalling pathways in epithelial cells via...
2.
Wickramasinghe D, Lyon C, Lee S, Hepworth O, Priest E, Maufrais C, et al.
mBio
. 2024 Jul;
15(8):e0335123.
PMID: 38953356
Importance: Fungal infections are a significant burden to health. Candidalysin is a toxin produced by that damages host tissues, facilitating infection. Previously, we demonstrated that candidalysins exist in the related...
3.
Sprague J, Schille T, Allert S, Trumper V, Lier A, Grossmann P, et al.
PLoS Pathog
. 2024 Mar;
20(3):e1012031.
PMID: 38427950
The opportunistic fungal pathogen Candida albicans thrives on human mucosal surfaces as a harmless commensal, but frequently causes infections under certain predisposing conditions. Translocation across the intestinal barrier into the...
4.
Muller R, Konig A, Groth S, Zarnowski R, Visser C, Handrianz T, et al.
Nat Microbiol
. 2024 Feb;
9(3):669-683.
PMID: 38388771
The opportunistic fungal pathogen Candida albicans damages host cells via its peptide toxin, candidalysin. Before secretion, candidalysin is embedded in a precursor protein, Ece1, which consists of a signal peptide,...
5.
Valentine M, Rudolph P, Dietschmann A, Tsavou A, Mogavero S, Lee S, et al.
mBio
. 2024 Feb;
15(3):e0340923.
PMID: 38349176
can cause mucosal infections in humans. This includes oropharyngeal candidiasis, which is commonly observed in human immunodeficiency virus infected patients, and vulvovaginal candidiasis (VVC), which is the most frequent manifestation...
6.
Launder D, Dillon J, Wuescher L, Glanz T, Abdul-Aziz N, Yi E, et al.
Mucosal Immunol
. 2024 Jan;
17(2):182-200.
PMID: 38246240
The fungus Candida albicans can cause mucosal infections including oropharyngeal candidiasis (OPC) in immunocompromised patients. In humans, an increased risk of fungal infections correlates with thrombocytopenia. However, our understanding of...
7.
Wu Y, Du S, Bimler L, Mauk K, Lortal L, Kichik N, et al.
Cell Rep
. 2023 Oct;
42(10):113240.
PMID: 37819761
The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer's disease (AD), but the molecular basis of brain anti-Candida immunity remains unknown. We show that C. ...
8.
Unger L, Skoluda S, Backman E, Amulic B, Ponce-Garcia F, Etiaba C, et al.
EMBO Rep
. 2023 Oct;
24(11):e57571.
PMID: 37795769
The peptide toxin candidalysin, secreted by Candida albicans hyphae, promotes stimulation of neutrophil extracellular traps (NETs). However, candidalysin alone triggers a distinct mechanism for NET-like structures (NLS), which are more...
9.
Dickenson R, Pellon A, Ponde N, Hepworth O, Daniels Gatward L, Naglik J, et al.
bioRxiv
. 2023 Apr;
PMID: 37066428
is a fungal pathobiont colonising mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, invades mucosal tissues activating EGFR-MAPK signalling pathways in epithelial cells via...
10.
Okaa U, Bertuzzi M, Fortune-Grant R, Thomson D, Moyes D, Naglik J, et al.
Infect Immun
. 2023 Jan;
91(2):e0033322.
PMID: 36625602
The human lung is constantly exposed to Aspergillus fumigatus spores, the most prevalent worldwide cause of fungal respiratory disease. Pulmonary tissue damage is a unifying feature of Aspergillus-related diseases; however,...