Jonathan P Godbout
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Explore the profile of Jonathan P Godbout including associated specialties, affiliations and a list of published articles.
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106
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7587
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Recent Articles
1.
Packer J, Giammo S, Wangler L, Davis A, Bray C, Godbout J
Res Sq
. 2025 Mar;
PMID: 40034431
Neuropsychiatric complications including depression and cognitive impairment develop, persist, and worsen in the years after traumatic brain injury (TBI), negatively affecting life and lifespan. Inflammatory responses mediated by microglia are...
2.
Biltz R, Yin W, Goodman E, Wangler L, Davis A, Oliver B, et al.
Brain Behav Immun Health
. 2024 Dec;
43:100908.
PMID: 39720627
Chronic stress increases the incidence of psychiatric disorders including anxiety, depression, and posttraumatic stress disorder. Repeated Social Defeat (RSD) in mice recapitulates several key physiological, immune, and behavioral changes evident...
3.
Nemeth D, Liu X, Monet M, Niu H, Maxey G, Schrier M, et al.
J Neuroinflammation
. 2024 Nov;
21(1):303.
PMID: 39563437
Interleukin-1 (IL-1) is a pro-inflammatory cytokine that exerts a wide range of neurological and immunological effects throughout the central nervous system (CNS) and is associated with the etiology of affective...
4.
Sweeney N, Kim T, Morrison C, Li L, Acosta D, Liang J, et al.
Acta Neuropathol
. 2024 Oct;
148(1):52.
PMID: 39394356
Growing evidence supports that early- or middle-life traumatic brain injury (TBI) is a risk factor for developing Alzheimer's disease (AD) and AD-related dementia (ADRD). Nevertheless, the molecular mechanisms underlying TBI-induced...
5.
Goodman E, DiSabato D, Sheridan J, Godbout J
Commun Biol
. 2024 Sep;
7(1):1199.
PMID: 39341879
Chronic stress is associated with anxiety and cognitive impairment. Repeated social defeat (RSD) in mice induces anxiety-like behavior driven by microglia and the recruitment of inflammatory monocytes to the brain....
6.
Brennan F, Swarts E, Kigerl K, Mifflin K, Guan Z, Noble B, et al.
Sci Transl Med
. 2024 Jun;
16(751):eadi3259.
PMID: 38865485
Robust structural remodeling and synaptic plasticity occurs within spinal autonomic circuitry after severe high-level spinal cord injury (SCI). As a result, normally innocuous visceral or somatic stimuli elicit uncontrolled activation...
7.
Goodman E, Biltz R, Packer J, DiSabato D, Swanson S, Oliver B, et al.
Mol Psychiatry
. 2024 Mar;
29(8):2321-2334.
PMID: 38459193
Chronic stress is associated with increased anxiety, cognitive deficits, and post-traumatic stress disorder. Repeated social defeat (RSD) in mice causes long-term stress-sensitization associated with increased microglia activation, monocyte accumulation, and...
8.
Packer J, Bray C, Beckman N, Wangler L, Davis A, Goodman E, et al.
Glia
. 2023 Nov;
72(2):300-321.
PMID: 37937831
Neuropsychiatric complications including depression and cognitive decline develop in the years after traumatic brain injury (TBI), negatively affecting quality of life. Microglial and type 1 interferon (IFN-I) responses are associated...
9.
Biltz R, Swanson S, Draime N, Davis A, Yin W, Goodman E, et al.
Brain Behav Immun
. 2023 Nov;
115:356-373.
PMID: 37914101
Chronic stress is linked to increased anxiety. Repeated social defeat (RSD) in mice causes anxiety that is dependent on activated neurons, reactive microglia, and accumulation of monocytes in the brain....
10.
Wangler L, Godbout J
Trends Neurosci
. 2023 Sep;
46(11):926-940.
PMID: 37723009
Most of the individuals who experience traumatic brain injury (TBI) develop neuropsychiatric and cognitive complications that negatively affect recovery and health span. Activation of multiple inflammatory pathways persists after TBI,...