Jonathan G Seidman
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Explore the profile of Jonathan G Seidman including associated specialties, affiliations and a list of published articles.
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151
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11146
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Recent Articles
11.
Fleischer S, Nash T, Tamargo M, Lock R, Venturini G, Morsink M, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(9):1123-1139.
PMID: 39195859
Systemic lupus erythematosus (SLE) is a heterogenous autoimmune disease that affects multiple organs, including the heart. The mechanisms of myocardial injury in SLE remain poorly understood. In this study, we...
12.
Shi W, Wasson L, Dorr K, Robbe Z, Wilczewski C, Hepperla A, et al.
Development
. 2024 Apr;
151(8).
PMID: 38619323
Regulation of chromatin states is essential for proper temporal and spatial gene expression. Chromatin states are modulated by remodeling complexes composed of components that have enzymatic activities. CHD4 is the...
13.
Fleischer S, Nash T, Tamargo M, Lock R, Venturini G, Morsink M, et al.
bioRxiv
. 2024 Apr;
PMID: 38559188
Systemic lupus erythematosus (SLE) is a highly heterogenous autoimmune disease that affects multiple organs, including the heart. The mechanisms by which myocardial injury develops in SLE, however, remain poorly understood....
14.
Ruan W, Li T, Lee J, Bang I, Deng W, Ma X, et al.
Res Sq
. 2024 Mar;
PMID: 38464103
Acute myocardial infarction stands as a prominent cause of morbidity and mortality worldwide. Clinical studies have demonstrated that the severity of cardiac injury following myocardial infarction exhibits a circadian pattern,...
15.
Yang J, Hayano M, Griffin P, Amorim J, Bonkowski M, Apostolides J, et al.
Cell
. 2024 Mar;
187(5):1312-1313.
PMID: 38428398
No abstract available.
16.
Xiao F, Zhang X, Morton S, Kim S, Fan Y, Gorham J, et al.
Nat Genet
. 2024 Feb;
56(3):420-430.
PMID: 38378865
Rare coding mutations cause ∼45% of congenital heart disease (CHD). Noncoding mutations that perturb cis-regulatory elements (CREs) likely contribute to the remaining cases, but their identification has been problematic. Using...
17.
Chen J, Zhang X, DeLaughter D, Trembley M, Saifee S, Xiao F, et al.
Circ Res
. 2024 Feb;
134(5):529-546.
PMID: 38348657
Background: Mature endothelial cells (ECs) are heterogeneous, with subtypes defined by tissue origin and position within the vascular bed (ie, artery, capillary, vein, and lymphatic). How this heterogeneity is established...
18.
Sweat M, Cao Y, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Arulsamy K, et al.
Nat Cardiovasc Res
. 2024 Feb;
2(10):881-898.
PMID: 38344303
Understanding how the atrial and ventricular heart chambers maintain distinct identities is a prerequisite for treating chamber-specific diseases. Here, we selectively knocked out (KO) the transcription factor in the atrial...
19.
Atsuta Y, Lee C, Rodrigues A, Colle C, Tomizawa R, Lujan E, et al.
Dev Cell
. 2024 Feb;
59(3):415-430.e8.
PMID: 38320485
The early limb bud consists of mesenchymal limb progenitors derived from the lateral plate mesoderm (LPM). The LPM also gives rise to the mesodermal components of the flank and neck....
20.
Barish S, Berg K, Drozd J, Berglund-Brown I, Khizir L, Wasson L, et al.
Development
. 2023 Dec;
150(23).
PMID: 38038666
De novo variants affecting monoubiquitylation of histone H2B (H2Bub1) are enriched in human congenital heart disease. H2Bub1 is required in stem cell differentiation, cilia function, post-natal cardiomyocyte maturation and transcriptional...