Christopher N Toepfer
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Explore the profile of Christopher N Toepfer including associated specialties, affiliations and a list of published articles.
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25
Citations
790
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Recent Articles
1.
Raj Murthi S, Petry A, Shashikadze B, Stockl J, Schmid M, Santamaria G, et al.
Sci Rep
. 2025 Jan;
15(1):2132.
PMID: 39820339
Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes coding for structural sarcomeric proteins, is the most common inherited heart disease. HCM is associated with myocardial hypertrophy, fibrosis and ventricular...
2.
Kim Y, Kim S, Saul D, Neyazi M, Schmid M, Wakimoto H, et al.
J Clin Invest
. 2024 Dec;
135(4).
PMID: 39688912
Heterozygous truncating variants in the sarcomere protein titin (TTN) are the most common genetic cause of heart failure. To understand mechanisms that regulate abundant cardiomyocyte (CM) TTN expression, we characterized...
3.
Zhang Y, Tan C, Toepfer C, Lu X, Bayley H
Science
. 2024 Nov;
386(6725):1024-1030.
PMID: 39607936
Hydrogel iontronic devices can emulate biological functions and communicate with living matter. But the fabrication of miniature, soft iontronic devices according to modular designs has not been achieved. In this...
4.
Ewoldt J, Wang M, McLellan M, Cloonan P, Chopra A, Gorham J, et al.
Sci Adv
. 2024 Oct;
10(42):eadi6927.
PMID: 39413182
Hypertrophic cardiomyopathy (HCM) is characterized by thickening of the left ventricular wall, diastolic dysfunction, and fibrosis, and is associated with mutations in genes encoding sarcomere proteins. While in vitro studies...
5.
Psaras Y, Toepfer C
Exp Physiol
. 2023 Dec;
109(2):175-189.
PMID: 38095849
Skeletal myopathies and ataxias with secondary cardiac involvement are complex, progressive and debilitating conditions. As life expectancy increases across these conditions, cardiac involvement often becomes more prominent. This highlights the...
6.
Robinson P, Sparrow A, Psaras Y, Steeples V, Simon J, Broyles C, et al.
J Mol Cell Cardiol
. 2023 May;
180:44-57.
PMID: 37127261
We compared commonly used BAPTA-derived chemical Ca dyes (fura2, Fluo-4, and Rhod-2) with a newer genetically encoded indicator (R-GECO) in single cell models of the heart. We assessed their performance...
7.
Venturini G, Alvim J, Padilha K, Toepfer C, Gorham J, Wasson L, et al.
Front Cell Infect Microbiol
. 2023 Feb;
13:1098457.
PMID: 36814444
Introduction: Chagas cardiomyopathy, a disease caused by () infection, is a major contributor to heart failure in Latin America. There are significant gaps in our understanding of the mechanism for...
8.
Margara F, Psaras Y, Wang Z, Schmid M, Doste R, Garfinkel A, et al.
Sci Rep
. 2022 Dec;
12(1):22501.
PMID: 36577774
Cardiomyopathies have unresolved genotype-phenotype relationships and lack disease-specific treatments. Here we provide a framework to identify genotype-specific pathomechanisms and therapeutic targets to accelerate the development of precision medicine. We use...
9.
Meier A, Raj Murthi S, Rawat H, Toepfer C, Santamaria G, Schmid M, et al.
iScience
. 2022 Jan;
25(1):103596.
PMID: 34988410
Childhood-onset myocardial hypertrophy and cardiomyopathic changes are associated with significant morbidity and mortality in early life, particularly in patients with Noonan syndrome, a multisystemic genetic disorder caused by autosomal dominant...
10.
Zhang K, Cloonan P, Sundaram S, Liu F, Das S, Ewoldt J, et al.
Sci Adv
. 2021 Oct;
7(42):eabh3995.
PMID: 34652945
Progressive loss of cardiac systolic function in arrhythmogenic cardiomyopathy (ACM) has recently gained attention as an important clinical consideration in managing the disease. However, the mechanisms leading to reduction in...