Jonas Abdel-Khalik
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Explore the profile of Jonas Abdel-Khalik including associated specialties, affiliations and a list of published articles.
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402
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Recent Articles
1.
Griffiths W, Abdel-Khalik J, Moore S, Wijeyekoon R, Crick P, Yutuc E, et al.
Front Aging Neurosci
. 2021 Sep;
13:685594.
PMID: 34526889
Disordered cholesterol metabolism is linked to neurodegeneration. In this study we investigated the profile of cholesterol metabolites found in the cerebrospinal fluid (CSF) of Parkinson's disease (PD) patients. When adjustments...
2.
Abdel-Khalik J, Hearn T, Dickson A, Crick P, Yutuc E, Austin-Muttitt K, et al.
J Steroid Biochem Mol Biol
. 2020 Nov;
206:105794.
PMID: 33246156
Bile acids are the end products of cholesterol metabolism secreted into bile. They are essential for the absorption of lipids and lipid soluble compounds from the intestine. Here we have...
3.
Crick P, Yutuc E, Abdel-Khalik J, Saeed A, Betsholtz C, Genove G, et al.
J Steroid Biochem Mol Biol
. 2019 Sep;
195:105475.
PMID: 31541728
While the presence and abundance of the major oxysterols and cholestenoic acids in the circulation is well established, minor cholesterol metabolites may also have biological importance and be of value...
4.
Griffiths W, Yutuc E, Abdel-Khalik J, Crick P, Hearn T, Dickson A, et al.
Free Radic Biol Med
. 2019 Apr;
144:124-133.
PMID: 31009661
Cholestane-3β,5α,6β-triol (3β,5α,6β-triol) is formed from cholestan-5,6-epoxide (5,6-EC) in a reaction catalysed by cholesterol epoxide hydrolase, following formation of 5,6-EC through free radical oxidation of cholesterol. 7-Oxocholesterol (7-OC) and 7β-hydroxycholesterol (7β-HC)...
5.
Abdel-Khalik J, Crick P, Yutuc E, Wang Y, Griffiths W
Molecules
. 2019 Feb;
24(3).
PMID: 30736477
Enzyme-assisted derivatization for sterol analysis (EADSA) is a technology designed to enhance sensitivity and specificity for sterol analysis using electrospray ionization⁻mass spectrometry. To date it has only been exploited on...
6.
Theofilopoulos S, Abreu de Oliveira W, Yang S, Yutuc E, Saeed A, Abdel-Khalik J, et al.
J Biol Chem
. 2019 Jan;
294(11):4169-4176.
PMID: 30655290
The liver X receptors Lxrα/NR1H3 and Lxrβ/NR1H2 are ligand-dependent nuclear receptors critical for midbrain dopaminergic (mDA) neuron development. We found previously that 24(),25-epoxycholesterol (24,25-EC), the most potent and abundant Lxr...
7.
Griffiths W, Abdel-Khalik J, Yutuc E, Roman G, Warner M, Gustafsson J, et al.
Free Radic Biol Med
. 2018 Dec;
134:42-52.
PMID: 30578919
Using liquid chromatography - mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21),...
8.
Griffiths W, Crick P, Meljon A, Theofilopoulos S, Abdel-Khalik J, Yutuc E, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2018 Nov;
1864(2):191-211.
PMID: 30471425
Cytochrome P450 (CYP) 27A1 is a key enzyme in both the acidic and neutral pathways of bile acid biosynthesis accepting cholesterol and ring-hydroxylated sterols as substrates introducing a (25R)26-hydroxy and...
9.
Abdel-Khalik J, Crick P, Yutuc E, DeBarber A, Duell P, Steiner R, et al.
Biochimie
. 2018 Jul;
153:86-98.
PMID: 29960034
Dihydroxyoxocholestenoic acids are intermediates in bile acid biosynthesis. Here, using liquid chromatography - mass spectrometry, we confirm the identification of 7α,24-dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acids in cerebrospinal fluid (CSF) based on...
10.
Griffiths W, Gilmore I, Yutuc E, Abdel-Khalik J, Crick P, Hearn T, et al.
J Lipid Res
. 2018 Apr;
59(6):1058-1070.
PMID: 29626102
7-Oxocholesterol (7-OC), 5,6-epoxycholesterol (5,6-EC), and its hydrolysis product cholestane-3β,5α,6β-triol (3β,5α,6β-triol) are normally minor oxysterols in human samples; however, in disease, their levels may be greatly elevated. This is the case...