Jon P Connelly
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Explore the profile of Jon P Connelly including associated specialties, affiliations and a list of published articles.
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39
Citations
964
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Recent Articles
1.
Pan M, Zhang Y, Wright W, Liu X, Passaia B, Currier D, et al.
Nat Commun
. 2025 Feb;
16(1):2036.
PMID: 40021625
Retinoic acid (RA) is a standard-of-care neuroblastoma drug thought to be effective by inducing differentiation. Curiously, RA has little effect on primary human tumors during upfront treatment but can eliminate...
2.
Baysoy A, Tian X, Zhang F, Renauer P, Bai Z, Shi H, et al.
bioRxiv
. 2024 Nov;
PMID: 39605490
Perturb-seq enabled the profiling of transcriptional effects of genetic perturbations in single cells but lacks the ability to examine the impact on tissue environments. We present Perturb-DBiT for simultaneous co-sequencing...
3.
Raynor J, Collins N, Shi H, Guy C, Saravia J, Lim S, et al.
Immunity
. 2024 Oct;
57(11):2597-2614.e13.
PMID: 39406246
Nutrient availability and organelle biology direct tissue homeostasis and cell fate, but how these processes orchestrate tissue immunity remains poorly defined. Here, using in vivo CRISPR-Cas9 screens, we uncovered organelle...
4.
Kardian A, Sun H, Ippagunta S, Laboe N, Chen H, Emanus E, et al.
bioRxiv
. 2024 Aug;
PMID: 39211123
Highlights: 1. Specific chromatin modules accessible during brain development render distinct cell lineage programs at risk of transformation by pediatric fusion oncoproteins.2. Cross-species single cell ATAC and RNA (scMultiome) of...
5.
Diedrich J, Dong Q, Ferguson D, Bergeron B, Autry R, Qian M, et al.
Leukemia
. 2024 Jul;
38(8):1867.
PMID: 38961139
No abstract available.
6.
Lillo Osuna M, Han L, Connelly J, Miller-Preutt S, Weiss M, Wlodarski M, et al.
Stem Cell Res
. 2024 Jun;
79:103479.
PMID: 38908299
Diamond-Blackfan anemia syndrome (DBAS) is an inherited bone marrow failure disorder that typically presents in infancy as hypoplastic anemia and developmental abnormalities in approximately 50% of cases. DBAS is caused...
7.
Yang J, Fang J, Singh S, Wells B, Wu Q, Janke L, et al.
Res Sq
. 2024 Jun;
PMID: 38853928
3D cellular-specific epigenetic and transcriptomic reprogramming is critical to organogenesis and tumorigenesis. Here we dissect the distinct cell fitness in 2D (normoxia vs. chronic hypoxia) vs 3D (normoxia) culture conditions...
8.
Bynigeri R, Malireddi R, Mall R, Connelly J, Pruett-Miller S, Kanneganti T
BMC Biol
. 2024 May;
22(1):122.
PMID: 38807188
Background: The innate immune system serves as the first line of host defense. Transforming growth factor-β-activated kinase 1 (TAK1) is a key regulator of innate immunity, cell survival, and cellular...
9.
Pan M, Zhang Y, Wright W, Liu X, Passaia B, Currier D, et al.
bioRxiv
. 2024 May;
PMID: 38798584
Retinoic acid (RA) is a standard-of-care neuroblastoma drug thought to be effective by inducing differentiation. Curiously, RA has little effect on primary human tumors during upfront treatment but can eliminate...
10.
Collins R, Gee R, Sanchez M, Tozandehjani S, Bayat T, Breznik B, et al.
bioRxiv
. 2024 May;
PMID: 38798351
Background: Medulloblastoma (MB) is the most malignant childhood brain cancer. Group 3 MB subtype accounts for about 25% of MB diagnoses and is associated with the most unfavorable outcomes. Herein,...