John W Weisel
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Explore the profile of John W Weisel including associated specialties, affiliations and a list of published articles.
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204
Citations
5751
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Recent Articles
21.
Lassila R, Weisel J
J Thromb Haemost
. 2023 May;
21(11):3024-3032.
PMID: 37210074
The multiple roles of red blood cells (RBCs) are often neglected as contributors in hemostasis and thrombosis. Proactive opportunities to increase RBC numbers, either acutely or subacutely in the case...
22.
23.
Litvinov R, Weisel J
Res Pract Thromb Haemost
. 2023 Feb;
7(1):100023.
PMID: 36760777
A State of the Art lecture titled "Blood Clot Contraction: Mechanisms, Pathophysiology, and Disease" was presented at the International Society on Thrombosis and Haemostasis (ISTH) Congress in 2022. This was...
24.
Garyfallogiannis K, Ramanujam R, Litvinov R, Yu T, Nagaswami C, Bassani J, et al.
Acta Biomater
. 2023 Jan;
159:49-62.
PMID: 36642339
The mechanical stability of blood clots necessary for their functions is provided by fibrin, a fibrous gel. Rupture of clots leads to life-threatening thrombotic embolization, which is little understood. Here,...
25.
Safiullina S, Evtugina N, Andrianova I, Khismatullin R, Kravtsova O, Khabirova A, et al.
Sci Rep
. 2022 Nov;
12(1):19975.
PMID: 36404341
Mutations in the MYH9 gene result in macrothrombocytopenia often associated with hemorrhages. Here, we studied the function and structure of platelets in three family members with a heterozygous mutation R1933X...
26.
Risman R, Abdelhamid A, Weisel J, Bannish B, Tutwiler V
Biophys J
. 2022 Aug;
121(17):3271-3285.
PMID: 35927957
Thrombosis, resulting in occlusive blood clots, blocks blood flow to downstream organs and causes life-threatening conditions such as heart attacks and strokes. The administration of tissue plasminogen activator (t-PA), which...
27.
Kim O, Litvinov R, Mordakhanova E, Bi E, Vagin O, Weisel J
iScience
. 2022 Jul;
25(7):104654.
PMID: 35832887
Although septins have been well-studied in nucleated cells, their role in anucleate blood platelets remains obscure. Here, we elucidate the contribution of septins to human platelet structure and functionality. We...
28.
Chronic Immune Platelet Activation Is Followed by Platelet Refractoriness and Impaired Contractility
Andrianova I, Khabirova A, Ponomareva A, Peshkova A, Evtugina N, Le Minh G, et al.
Int J Mol Sci
. 2022 Jul;
23(13).
PMID: 35806341
Autoimmune diseases, including systemic lupus erythematosus (SLE), have a high risk of thrombotic and hemorrhagic complications associated with altered platelet functionality. We studied platelets from the blood of SLE patients...
29.
Spiewak R, Gosselin A, Merinov D, Litvinov R, Weisel J, Tutwiler V, et al.
J Mech Behav Biomed Mater
. 2022 Jul;
133:105328.
PMID: 35803206
Blood clots form at the site of vascular injury to seal the wound and prevent bleeding. Clots are in tension as they perform their biological functions and withstand hydrodynamic forces...
30.
Pancaldi F, Kim O, Weisel J, Alber M, Xu Z
Curr Opin Biomed Eng
. 2022 Apr;
22.
PMID: 35386550
Fibrin deformation and interaction of fibrin with other blood components play critical roles in hemostasis and thrombosis. In this review, computational and mathematical biomechanical models of fibrin network deformation and...