John T Welch
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Explore the profile of John T Welch including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Biswas S, Pathak N, Sutherland L, Chen A, Welch J
Phys Chem Chem Phys
. 2025 Jan;
27(4):2001-2010.
PMID: 39749565
The influence of aqueous solutions of 2-(tetrafluoro(trifluoromethyl)-λ-sulfanyl-ethan-1-ol (CFSF-ethanol) and 2,2,2-trifluoroethanol (TFE) on the secondary structure of melittin was studied using circular dichroism (CD) and molecular dynamics (MD) simulations. In water,...
2.
Bonetti K, Rende D, Murphy M, Welch J
Molecules
. 2024 Sep;
29(18).
PMID: 39339408
Novel tetrafluoro-λ-sulfanyl-containing oligomers prepared by visible light-promoted addition of 1,4-(bis-chlorotetrafluoro-λ-sulfanyl) benzene or 1,3-(bis-chlorotetrafluoro-λ-sulfanyl) benzene to either 1,4-diethynyl benzene or the 1,3-diethynyl isomers form hard, stress resistant thin films on spin...
3.
Deng M, Wilde M, Welch J
J Org Chem
. 2023 Nov;
88(22):15639-15646.
PMID: 37934773
A practical synthetic path for the preparation of -CFSF-substituted amines has been described. Primary and secondary amines bearing a variety of different functional groups including amino acids, cyclic amines, and...
4.
Biswas S, Kaur S, Myers C, Chen A, Welch J
ACS Omega
. 2023 Aug;
8(33):30037-30047.
PMID: 37636933
2-Tetrafluoro(trifluoromethyl)-λ-sulfanylethan-1-ol (CFSF-ethanol) combines the polar hydrophobicity of tetrafluoro(trifluoromethyl)-λ-sulfanyl (CFSF) group with the polarity of simple alcohols. The properties of aqueous solutions of the well-known fluorinated alcohols 2,2,2-trifluoroethanol (TFE) and 1,1,1,3,3,3-hexafluoroisopropanol...
5.
Synthesis of -Tetrafluoro(trifluoromethyl)-λ-sulfanyl (CFSF)-Containing Olefins via Cross Metathesis
Deng M, Wilde M, Welch J
J Org Chem
. 2023 Jul;
88(15):11363-11366.
PMID: 37449734
The cross-metathesis reactions of -tetrafluoro(trifluoromethyl)-λ-sulfanyl (CFSF)-containing olefins expand the repertoire of synthetic transformations of CFSF-substituted molecules. Treatment of a primary alkene and 3-CFSF-propene with a second-generation Hoveyda-Grubbs catalyst yielded the...
6.
Ikeda A, Capellan A, Welch J
Org Biomol Chem
. 2019 Aug;
17(35):8079-8082.
PMID: 31454017
Site specific introduction of the polar hydrophobic trifluoromethyl-λ-tetrafluorosulfanyl (CFSF) group can effectively control the secondary structure of a heptapeptide, the minimum repeat unit of an α-helix. The structural influence of...
7.
Seeley J, Cotlet M, Eagleton A, Higashiya S, Welch J
Chemistry
. 2018 Nov;
25(4):961-965.
PMID: 30414202
The fluorescence intensity of a C-terminal acceptor chromophore, N-(7-dimethylamino-4-methyl coumarin (DACM), increased proportionally with 280 nm irradiation of an increasing number of donor tryptophan residues located on a β-sheet forming...
8.
Montgomery S, Young E, Durham P, Zulauf K, Rank L, Miller B, et al.
PLoS One
. 2018 Sep;
13(9):e0204495.
PMID: 30261007
New therapeutic strategies are needed to treat drug resistant tuberculosis (TB) and to improve treatment for drug sensitive TB. Pyrazinamide (PZA) is a critical component of current first-line TB therapy....
9.
Baron S, Peleg Y, Grunwald J, Morgenstern D, Elad N, Peretz M, et al.
PLoS One
. 2018 Sep;
13(9):e0204457.
PMID: 30248156
Background: Fatty acid synthase 1 (FAS I) from Mycobacterium tuberculosis (Mtb) is an essential protein and a promising drug target. FAS I is a multi-functional, multi-domain protein that is organized...
10.
Savoie P, von Hahmann C, Penger A, Wei Z, Welch J
Org Biomol Chem
. 2018 Apr;
16(17):3151-3159.
PMID: 29645036
The influence of pentafluorosulfanylation on biological activity has been revealed in numerous comparative studies of biologically active compounds, but considerably less is known about the influence of pentafluorosulfanylation on reactivity....