John Rooney
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Explore the profile of John Rooney including associated specialties, affiliations and a list of published articles.
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Citations
237
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Recent Articles
1.
OBrien J, Mitchell C, Auerbach S, Doonan L, Ewald J, Everett L, et al.
Toxicol Sci
. 2024 Nov;
203(2):147-159.
PMID: 39499193
There is a pressing need to increase the efficiency and reliability of toxicological safety assessment for protecting human health and the environment. Although conventional toxicology tests rely on measuring apical...
2.
Daniel A, Choksi N, Abedini J, Bell S, Ceger P, Cook B, et al.
Front Toxicol
. 2022 Nov;
4:987848.
PMID: 36408349
Humans are exposed to large numbers of chemicals during their daily activities. To assess and understand potential health impacts of chemical exposure, investigators and regulators need access to reliable toxicity...
3.
Rooney J, Wehmas L, Ryan N, Chorley B, Hester S, Kenyon E, et al.
Toxicology
. 2021 Nov;
465:153046.
PMID: 34813904
Short-term biomarkers of toxicity have an increasingly important role in the screening and prioritization of new chemicals. In this study, we examined early indicators of liver toxicity for three reference...
4.
Allen D, Rooney J, Kleinstreuer N, Lowit A, Perron M
ALTEX
. 2021 Mar;
38(3):463-476.
PMID: 33712859
Dermal toxicity is driven by the ability of a substance to penetrate the skin. The “triple pack” approach, which combines in vivo rat, in vitro rat, and in vitro human...
5.
Rooney J, Ryan N, Liu J, Houtman R, van Beuningen R, Hsieh J, et al.
Chem Res Toxicol
. 2021 Jan;
34(2):313-329.
PMID: 33405908
Identification of chemicals that affect hormone-regulated systems will help to predict endocrine disruption. In our previous study, a 46 gene biomarker was found to be an accurate predictor of estrogen...
6.
Thresholds Derived From Common Measures in Rat Studies Are Predictive of Liver Tumorigenic Chemicals
Corton J, Korunes K, Abedini J, El-Masri H, Brown J, Paul-Friedman K, et al.
Toxicol Pathol
. 2020 Oct;
48(7):857-874.
PMID: 33084515
We hypothesized that typical tissue and clinical chemistry (ClinChem) end points measured in rat toxicity studies exhibit chemical-independent biological thresholds beyond which cancer occurs. Using the rat in vivo TG-GATES...
7.
Corton J, Hill T, Sutherland J, Stevens J, Rooney J
Toxicol Sci
. 2020 Jul;
177(1):11-26.
PMID: 32603430
Chemical-induced liver cancer occurs in rodents through well-characterized adverse outcome pathways. We hypothesized that measurement of the 6 most common molecular initiating events (MIEs) in liver cancer adverse outcome pathways...
8.
Hill T, Rooney J, Abedini J, El-Masri H, Wood C, Corton J
Toxicol Sci
. 2020 Jul;
177(1):41-59.
PMID: 32603419
Traditional methods for cancer risk assessment are resource-intensive, retrospective, and not feasible for the vast majority of environmental chemicals. In this study, we investigated whether quantitative genomic data from short-term...
9.
Bell S, Abedini J, Ceger P, Chang X, Cook B, Karmaus A, et al.
Toxicol In Vitro
. 2020 Jun;
67:104916.
PMID: 32553663
Moving toward species-relevant chemical safety assessments and away from animal testing requires access to reliable data to develop and build confidence in new approaches. The Integrated Chemical Environment (ICE) provides...
10.
Rooney J, Oshida K, Vasani N, Vallanat B, Ryan N, Chorley B, et al.
PLoS One
. 2018 Aug;
13(8):e0200004.
PMID: 30114225
The transcription factor Nrf2 (encoded by Nfe2l2) induces expression of numerous detoxifying and antioxidant genes in response to oxidative stress. The cytoplasmic protein Keap1 interacts with and represses Nrf2 function....