Nicole Kleinstreuer
Overview
Explore the profile of Nicole Kleinstreuer including associated specialties, affiliations and a list of published articles.
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86
Citations
3105
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Recent Articles
1.
Blum J, Brull M, Hengstler J, Dietrich D, Gruber A, Dipalo M, et al.
ALTEX
. 2025 Jan;
42(1):167-180.
PMID: 39817434
Toxicological test methods generate raw data and provide instructions on how to use these to determine a final outcome such as a classification of test compounds as hits or non-hits....
2.
Hartung T, Kleinstreuer N
ALTEX
. 2025 Jan;
42(1):3-21.
PMID: 39815689
The integration of artificial intelligence (AI) into new approach methods (NAMs) for toxicology rep-resents a paradigm shift in chemical safety assessment. Harnessing AI appropriately has enormous potential to streamline validation...
3.
Tieghi R, Moreira-Filho J, Martin H, Wellnitz J, Otoch M, Rath M, et al.
Toxics
. 2024 Nov;
12(11).
PMID: 39590983
Skin sensitization is a significant concern for chemical safety assessments. Traditional animal assays often fail to predict human responses accurately, and ethical constraints limit the collection of human data, necessitating...
4.
Hartung T, King N, Kleinstreuer N, Leist M, Tagle D
ALTEX
. 2024 Oct;
41(4):545-566.
PMID: 39440996
This article explores the potential of principles established in translational medicine for the use of bio-markers to advance the validation of alternatives to animal testing in preclinical safety assessment. It...
5.
Gao Y, Mughal Z, Jaramillo-Villegas J, Corradi M, Borrel A, Lieberman B, et al.
ArXiv
. 2024 Sep;
PMID: 39253636
Researchers in biomedical research, public health and the life sciences often spend weeks or months discovering, accessing, curating, and integrating data from disparate sources, significantly delaying the onset of actual...
6.
Marciano L, Kleinstreuer N, Chang X, Costa L, Silverio A, Martins I
Sci Total Environ
. 2024 Sep;
953:176003.
PMID: 39236816
Brazil stands as the world's leading coffee producer, where the extensive use of pesticides is economically critical yet poses health and environmental risks due to their non-selective mechanisms of action....
7.
Moreira-Filho J, Ranganath D, Conway M, Schmitt C, Kleinstreuer N, Mansouri K
J Cheminform
. 2024 Aug;
16(1):101.
PMID: 39152469
With the increased availability of chemical data in public databases, innovative techniques and algorithms have emerged for the analysis, exploration, visualization, and extraction of information from these data. One such...
8.
Mansouri K, Taylor K, Auerbach S, Ferguson S, Frawley R, Hsieh J, et al.
Environ Health Perspect
. 2024 Aug;
132(8):85002.
PMID: 39106156
Background: The field of toxicology has witnessed substantial advancements in recent years, particularly with the adoption of new approach methodologies (NAMs) to understand and predict chemical toxicity. Class-based methods such...
9.
Ehrlich D, Krishna S, Kleinstreuer N
ALTEX
. 2024 Jul;
41(4):617-632.
PMID: 38979646
Dysregulation of vascular endothelial growth factor (VEGF) and its receptor (VEGFR) contributes to atherosclerosis and cardiovascular disease (CVD), making it a potential target for CVD risk assessment. High-throughput screening (HTS)...
10.
Sakamuru S, Ma D, Pierro J, Baker N, Kleinstreuer N, Cali J, et al.
Biotechnol J
. 2024 Jun;
19(6):e2300659.
PMID: 38863121
All-trans retinoic acid (atRA) is an endogenous ligand of the retinoic acid receptors, which heterodimerize with retinoid X receptors. AtRA is generated in tissues from vitamin A (retinol) metabolism to...