John R McPherson
Overview
Explore the profile of John R McPherson including associated specialties, affiliations and a list of published articles.
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21
Citations
3572
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Recent Articles
1.
Alexandrov L, Kim J, Haradhvala N, Huang M, Ng A, Wu Y, et al.
Nature
. 2023 Jan;
614(7948):E41.
PMID: 36697836
No abstract available.
2.
Alexandrov L, Kim J, Haradhvala N, Huang M, Ng A, Wu Y, et al.
Nature
. 2020 Feb;
578(7793):94-101.
PMID: 32025018
Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG)...
3.
Tang Y, Ho S, Tan E, Ng A, McPherson J, Goh G, et al.
Breast Cancer Res
. 2018 Mar;
20(1):22.
PMID: 29566768
Background: Phosphatase and tensin homolog (PTEN) is one of the most frequently inactivated tumor suppressors in breast cancer. While PTEN itself is not considered a druggable target, PTEN synthetic-sick or...
4.
Jusakul A, Cutcutache I, Yong C, Lim J, Huang M, Padmanabhan N, et al.
Cancer Discov
. 2017 Jul;
7(10):1116-1135.
PMID: 28667006
Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries, combining whole-genome (71 cases), targeted/exome, copy-number, gene expression,...
5.
Low Y, Blocker C, McPherson J, Tang S, Cheng Y, Wong J, et al.
Cancer Lett
. 2017 Jun;
403:13-20.
PMID: 28624625
Approximately 20% early-stage (I/II) colorectal cancer (CRC) patients develop metastases despite curative surgery. We aim to develop a formalin-fixed and paraffin-embedded (FFPE)-based predictor of metastases in early-stage, clinically-defined low risk,...
6.
Wang C, McPherson J, Zhang L, Rozen S, Sabapathy K
DNA Repair (Amst)
. 2016 Sep;
46:9-19.
PMID: 27650847
Pseudomonas aeruginosa is an opportunistic pathogen which infects cystic fibrosis and cancer patients with compromised immune systems. LasR is a master regulator which controls the virulence of P. aeruginosa in...
7.
Huang K, Jang K, Kim S, Kim H, Kim S, Kwon H, et al.
Sci Rep
. 2016 Jan;
6:19552.
PMID: 26790612
Dacomitinib, an irreversible pan-HER inhibitor, had shown modest clinical activity in squamous cell carcinoma of head and neck (SCCHN) patients. Therefore, validated predictive biomarkers are required to identify patients most...
8.
Tan J, Ong C, Lim W, Ng C, Thike A, Ng L, et al.
Nat Genet
. 2015 Oct;
47(11):1341-5.
PMID: 26437033
Breast fibroepithelial tumors comprise a heterogeneous spectrum of pathological entities, from benign fibroadenomas to malignant phyllodes tumors. Although MED12 mutations have been frequently found in fibroadenomas and phyllodes tumors, the...
9.
Vettore A, Ramnarayanan K, Poore G, Lim K, Ong C, Huang K, et al.
Genome Med
. 2015 Sep;
7:98.
PMID: 26395002
Background: Carcinoma of the oral tongue (OTSCC) is the most common malignancy of the oral cavity, characterized by frequent recurrence and poor survival. The last three decades has witnessed a...
10.
Huang K, McPherson J, Tay S, Das K, Tan I, Ng C, et al.
Gut
. 2015 Sep;
65(12):1960-1972.
PMID: 26338826
Background: GI stromal tumours (GISTs) are clinically heterogenous exhibiting varying degrees of disease aggressiveness in individual patients. Objectives: We sought to identify genetic alterations associated with high-risk GIST, explore their...