John R McAnally
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Explore the profile of John R McAnally including associated specialties, affiliations and a list of published articles.
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30
Citations
3188
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Recent Articles
1.
Gan P, Wang Z, Bezprozvannaya S, McAnally J, Tan W, Li H, et al.
Cardiovasc Res
. 2023 Oct;
120(1):56-68.
PMID: 37890031
Aims: RNA binding proteins play essential roles in mediating RNA splicing and are key post-transcriptional regulators in the heart. Our recent study demonstrated that RBPMS (RNA binding protein with multiple...
2.
Lebek S, Caravia X, Straub L, Alzhanov D, Tan W, Li H, et al.
J Clin Invest
. 2023 Oct;
134(1).
PMID: 37856214
Cardiovascular diseases are the most common cause of worldwide morbidity and mortality, highlighting the necessity for advanced therapeutic strategies. Ca2+/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is a prominent inducer of various...
3.
Lebek S, Caravia X, Chemello F, Tan W, McAnally J, Chen K, et al.
Circulation
. 2023 Sep;
148(19):1490-1504.
PMID: 37712250
Background: Cardiovascular diseases are the main cause of worldwide morbidity and mortality, highlighting the need for new therapeutic strategies. Autophosphorylation and subsequent overactivation of the cardiac stress-responsive enzyme CaMKIIδ (Ca/calmodulin-dependent...
4.
Dos Santos M, Shah A, Zhang Y, Bezprozvannaya S, Chen K, Xu L, et al.
Nat Commun
. 2023 Jul;
14(1):4333.
PMID: 37468485
Skeletal muscle fibers express distinct gene programs during development and maturation, but the underlying gene regulatory networks that confer stage-specific myofiber properties remain unknown. To decipher these distinctive gene programs...
5.
Zhang Y, Ramirez-Martinez A, Chen K, McAnally J, Cai C, Durbacz M, et al.
J Clin Invest
. 2023 Jul;
133(13).
PMID: 37395273
Mutations in genes encoding nuclear envelope proteins lead to diseases known as nuclear envelopathies, characterized by skeletal muscle and heart abnormalities, such as Emery-Dreifuss muscular dystrophy (EDMD). The tissue-specific role...
6.
Chai A, Cui M, Chemello F, Li H, Chen K, Tan W, et al.
Nat Med
. 2023 Feb;
29(2):401-411.
PMID: 36797478
The most common form of genetic heart disease is hypertrophic cardiomyopathy (HCM), which is caused by variants in cardiac sarcomeric genes and leads to abnormal heart muscle thickening. Complications of...
7.
Nishiyama T, Zhang Y, Cui M, Li H, Sanchez-Ortiz E, McAnally J, et al.
Sci Transl Med
. 2022 Nov;
14(672):eade1633.
PMID: 36417486
Mutations in RNA binding motif protein 20 () are a common cause of familial dilated cardiomyopathy (DCM). Many mutations cluster within an arginine/serine-rich (RS-rich) domain, which mediates nuclear localization. These...
8.
Caravia X, Ramirez-Martinez A, Gan P, Wang F, McAnally J, Xu L, et al.
J Clin Invest
. 2022 Nov;
132(22).
PMID: 36377660
Mutations in nuclear envelope proteins (NEPs) cause devastating genetic diseases, known as envelopathies, that primarily affect the heart and skeletal muscle. A mutation in the NEP LEM domain-containing protein 2...
9.
Zhang Y, Li H, Nishiyama T, McAnally J, Sanchez-Ortiz E, Huang J, et al.
Mol Ther Nucleic Acids
. 2022 Aug;
29:525-537.
PMID: 36035749
Duchenne muscular dystrophy (DMD) is a lethal neuromuscular disease caused by mutations in the X-linked dystrophin () gene. Exon deletions flanking exon 51, which disrupt the dystrophin open reading frame...
10.
Ramirez-Martinez A, Zhang Y, van den Boogaard M, McAnally J, Rodriguez-Caycedo C, Chai A, et al.
J Clin Invest
. 2022 Jun;
132(11).
PMID: 35642635
Skeletal muscle fibers contain hundreds of nuclei, which increase the overall transcriptional activity of the tissue and perform specialized functions. Multinucleation occurs through myoblast fusion, mediated by the muscle fusogens...