John R Kelsoe
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Explore the profile of John R Kelsoe including associated specialties, affiliations and a list of published articles.
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147
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6328
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Recent Articles
1.
Mishra H, Wei H, LeRoux M, Ko D, Rohr K, Nievergelt C, et al.
FEBS J
. 2025 Feb;
PMID: 39995020
Bipolar disorder (BD) is characterized by disrupted circadian rhythms and neuronal loss. Lithium amplifies circadian rhythms and is neuroprotective, indicating mechanistic overlap across cellular systems. We examined the role of...
2.
OConnell K, Koromina M, van der Veen T, Boltz T, David F, Yang J, et al.
Nature
. 2025 Jan;
PMID: 39843750
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants...
3.
Lee H, Lee B, Shekhtman T, Park Y, Kelsoe J
Clin Psychopharmacol Neurosci
. 2024 Oct;
22(4):585-593.
PMID: 39420606
Objective: Bipolar disorder (BD) is marked by significant change in mood and energy levels with sleep disturbance a common feature, resulting in diminished quality of life and impaired daily functioning....
4.
Park Y, Lee B, Shekhtman T, Kelsoe J
J Affect Disord
. 2024 Aug;
367:31-37.
PMID: 39142578
Background: We assessed the association of prescription data with clinical manifestations and polygenic risk scores (PRS) in patients with bipolar I disorder. Methods: We enrolled 1471 individuals with BID and...
5.
Mishra H, Wei H, LeRoux M, Ko I, Rohr K, Nievergelt C, et al.
Res Sq
. 2024 May;
PMID: 38746315
Bipolar disorder (BD) is characterized by disrupted circadian rhythms and neuronal loss. Lithium is neuroprotective and used to treat BD, but outcomes are variable. Past research identified that circadian rhythms...
6.
Liu J, Huang X, Bao Y, Lu L, Dong P, Wolkowitz O, et al.
Mol Psychiatry
. 2024 Mar;
29(8):2560-2567.
PMID: 38480874
Background: Painful physical symptoms (PPS) are highly prevalent in patients with major depressive disorder (MDD). Presence of PPS in depressed patients are potentially associated with poorer antidepressant treatment outcome. We...
7.
Koromina M, Ravi A, Panagiotaropoulou G, Schilder B, Humphrey J, Braun A, et al.
medRxiv
. 2024 Feb;
PMID: 38405768
Bipolar disorder (BD) is a heritable mental illness with complex etiology. While the largest published genome-wide association study identified 64 BD risk loci, the causal SNPs and genes within these...
8.
Ou A, Rosenthal S, Adli M, Akiyama K, Akula N, Alda M, et al.
Transl Psychiatry
. 2024 Feb;
14(1):109.
PMID: 38395906
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study...
9.
Docherty A, Mullins N, Ashley-Koch A, Qin X, Coleman J, Shabalin A, et al.
Am J Psychiatry
. 2023 Oct;
180(10):723-738.
PMID: 37777856
Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt...
10.
Mizrahi L, Choudhary A, Ofer P, Goldberg G, Milanesi E, Kelsoe J, et al.
Mol Psychiatry
. 2023 Jul;
28(10):4280-4293.
PMID: 37488168
Bipolar disorder (BD) is a neuropsychiatric mood disorder manifested by recurrent episodes of mania and depression. More than half of BD patients are non-responsive to lithium, the first-line treatment drug,...