John M Parant
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Explore the profile of John M Parant including associated specialties, affiliations and a list of published articles.
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29
Citations
2745
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Recent Articles
1.
VanWinkle P, Wynn B, Lee E, Nawara T, Thomas H, Parant J, et al.
Cells Tissues Organs
. 2024 Jul;
1-19.
PMID: 38964305
Introduction: The formation of normal bone and bone healing requires the cAMP-responsive element binding protein 3-like-1 (Creb3l1) transmembrane transcription factor, as deletion of the murine CREB3L1 results in osteopenic animals...
2.
Karuppasamy M, English K, Henry C, Manzini M, Parant J, Wright M, et al.
Dis Model Mech
. 2024 Jan;
17(1).
PMID: 38235578
Skeletal muscular diseases predominantly affect skeletal and cardiac muscle, resulting in muscle weakness, impaired respiratory function and decreased lifespan. These harmful outcomes lead to poor health-related quality of life and...
3.
Wang J, Thomas H, Thompson R, Waldrep S, Fogerty J, Song P, et al.
Dis Model Mech
. 2022 Dec;
15(12).
PMID: 36533556
Meckel syndrome, nephronophthisis, Joubert syndrome and Bardet-Biedl syndrome are caused by mutations in proteins that localize to the ciliary transition zone (TZ). The phenotypically distinct syndromes suggest that these TZ...
4.
Li Z, Zimmerman K, Cherakara S, Chumley P, Collawn J, Wang J, et al.
Dis Model Mech
. 2022 Dec;
16(1).
PMID: 36457161
Although renal macrophages have been shown to contribute to cyst development in polycystic kidney disease (PKD) animal models, it remains unclear whether there is a specific macrophage subpopulation involved. Here,...
5.
Wang J, Thomas H, Chen Y, Percival S, Waldrep S, Ramaker R, et al.
PLoS Genet
. 2022 Aug;
18(8):e1010341.
PMID: 35994499
Sister chromatid cohesion (SCC) is an important process in chromosome segregation. ESCO2 is essential for establishment of SCC and is often deleted/altered in human cancers. We demonstrate that esco2 haploinsufficiency...
6.
Bentley-Ford M, LaBonty M, Thomas H, Haycraft C, Scott M, LaFayette C, et al.
Genetics
. 2021 Dec;
220(1).
PMID: 34850872
Primary cilia are sensory and signaling hubs with a protein composition that is distinct from the rest of the cell due to the barrier function of the transition zone (TZ)...
7.
Wang J, Thomas H, Li Z, Yeo N, Scott H, Dang N, et al.
Cell Death Dis
. 2021 Jul;
12(7):659.
PMID: 34193827
Cellular stress can lead to several human disease pathologies due to aberrant cell death. The p53 family (tp53, tp63, and tp73) and downstream transcriptional apoptotic target genes (PUMA/BBC3 and NOXA/PMAIP1)...
8.
Mannucci I, Dang N, Huber H, Murry J, Abramson J, Althoff T, et al.
Genome Med
. 2021 May;
13(1):90.
PMID: 34020708
Background: We aimed to define the clinical and variant spectrum and to provide novel molecular insights into the DHX30-associated neurodevelopmental disorder. Methods: Clinical and genetic data from affected individuals were...
9.
Cevallos R, Edwards Y, Parant J, Yoder B, Hu K
Sci Rep
. 2020 Nov;
10(1):19710.
PMID: 33184372
The four transcription factors OCT4, SOX2, KLF4, and MYC (OSKM) together can convert human fibroblasts to induced pluripotent stem cells (iPSCs). It is, however, perplexing that they can do so...
10.
Chumley P, Zhou J, Mrug S, Chacko B, Parant J, Challa A, et al.
Am J Physiol Renal Physiol
. 2018 Dec;
316(3):F414-F425.
PMID: 30566001
Deficiency in polycystin 1 triggers specific changes in energy metabolism. To determine whether defects in other human cystoproteins have similar effects, we studied extracellular acidification and glucose metabolism in human...