John M Dietschy
Overview
Explore the profile of John M Dietschy including associated specialties, affiliations and a list of published articles.
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30
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2207
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Recent Articles
1.
Jones R, Repa J, Russell D, Dietschy J, Turley S
Am J Physiol Gastrointest Liver Physiol
. 2012 May;
303(2):G263-74.
PMID: 22628034
Cholesterol 7α-hydroxylase (CYP7A1) is the initiating and rate-limiting enzyme in the neutral pathway that converts cholesterol to primary bile acids (BA). CYP7A1-deficient (Cyp7a1(-/-)) mice have a depleted BA pool, diminished...
2.
Aqul A, Liu B, Ramirez C, Pieper A, Estill S, Burns D, et al.
J Neurosci
. 2011 Jun;
31(25):9404-13.
PMID: 21697390
While unesterified cholesterol (C) is essential for remodeling neuronal plasma membranes, its role in certain neurodegenerative disorders remains poorly defined. Uptake of sterol from pericellular fluid requires processing that involves...
3.
Ramirez C, Liu B, Aqul A, Taylor A, Repa J, Turley S, et al.
J Lipid Res
. 2011 Feb;
52(4):688-98.
PMID: 21289032
Lipoprotein cholesterol taken up by cells is processed in the endosomal/lysosomal (E/L) compartment by the sequential action of lysosomal acid lipase (LAL), Niemann-Pick C2 (NPC2), and Niemann-Pick C1 (NPC1). Inactivation...
4.
Turley S, Valasek M, Repa J, Dietschy J
Am J Physiol Gastrointest Liver Physiol
. 2010 Aug;
299(5):G1012-22.
PMID: 20724527
Cholesterol homeostasis in the enterocyte is regulated by the interplay of multiple genes that ultimately determines the net amount of cholesterol reaching the circulation from the small intestine. The effect...
5.
Ramirez C, Liu B, Taylor A, Repa J, Burns D, Weinberg A, et al.
Pediatr Res
. 2010 Jun;
68(4):309-15.
PMID: 20581737
Niemann-Pick type C1 (NPC1) disease arises from a mutation inactivating NPC1 protein that normally moves unesterified cholesterol from the late endosomal/lysosomal complex of cells to the cytosolic compartment for processing....
6.
Liu B, Ramirez C, Miller A, Repa J, Turley S, Dietschy J
J Lipid Res
. 2009 Dec;
51(5):933-44.
PMID: 19965601
A mutation in NPC1 leads to sequestration of unesterified cholesterol in the late endosomal/lysosomal compartment of every cell culminating in the development of pulmonary, hepatic, and neurodegenerative disease. Acute administration...
7.
Xie C, Turley S, Dietschy J
J Lipid Res
. 2009 Mar;
50(7):1316-29.
PMID: 19286647
This study uses the mouse to explore the role of ABCA1 in the movement of this cholesterol from the peripheral organs to the endocrine glands for hormone synthesis and liver...
8.
Liu B, Turley S, Burns D, Miller A, Repa J, Dietschy J
Proc Natl Acad Sci U S A
. 2009 Jan;
106(7):2377-82.
PMID: 19171898
Niemann-Pick type C disease is largely attributable to an inactivating mutation of NPC1 protein, which normally aids movement of unesterified cholesterol (C) from the endosomal/lysosomal (E/L) compartment to the cytosolic...
9.
Dietschy J
Biol Chem
. 2009 Jan;
390(4):287-93.
PMID: 19166320
The average amount of cholesterol in the whole animal equals approximately 2100 mg/kg body weight, and 15% and 23% of this sterol in the mouse and human, respectively, is found...
10.
Valasek M, Repa J, Quan G, Dietschy J, Turley S
Am J Physiol Gastrointest Liver Physiol
. 2008 Aug;
295(4):G813-22.
PMID: 18718997
Niemann-Pick C1-like 1 (NPC1L1) facilitates the uptake of sterols into the enterocyte and is the target of the novel cholesterol absorption inhibitor, ezetimibe. These studies used the Golden Syrian hamster...