John Little 4th
Overview
Explore the profile of John Little 4th including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
267
Followers
0
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Recent Articles
1.
Hahn H, Daly C, Little 4th J, Perry-Hauser N, Flores-Espinoza E, Inoue A, et al.
Elife
. 2025 Feb;
13.
PMID: 39992711
Chemokine receptors are GPCRs that regulate the chemotactic migration of a wide variety of cells including immune and cancer cells. Most chemokine receptors contain features associated with the ability to...
2.
Sokrat B, Nguyen A, Thomsen A, Huang L, Kobayashi H, Kahsai A, et al.
Commun Biol
. 2024 Jul;
7(1):826.
PMID: 38972875
Classically, G protein-coupled receptors (GPCRs) promote signaling at the plasma membrane through activation of heterotrimeric Gαβγ proteins, followed by the recruitment of GPCR kinases and βarrestin (βarr) to initiate receptor...
3.
Nguyen A, Thomsen A, Cahill 3rd T, Huang R, Huang L, Marcink T, et al.
Nat Struct Mol Biol
. 2019 Nov;
26(12):1123-1131.
PMID: 31740855
Classically, G-protein-coupled receptors (GPCRs) are thought to activate G protein from the plasma membrane and are subsequently desensitized by β-arrestin (β-arr). However, some GPCRs continue to signal through G protein...
4.
Cahill 3rd T, Thomsen A, Tarrasch J, Plouffe B, Nguyen A, Yang F, et al.
Proc Natl Acad Sci U S A
. 2017 Feb;
114(10):2562-2567.
PMID: 28223524
β-Arrestins (βarrs) interact with G protein-coupled receptors (GPCRs) to desensitize G protein signaling, to initiate signaling on their own, and to mediate receptor endocytosis. Prior structural studies have revealed two...