John E Dominy Jr
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Explore the profile of John E Dominy Jr including associated specialties, affiliations and a list of published articles.
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14
Citations
1031
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Recent Articles
1.
Dominy Jr J, Lee Y, Jedrychowski M, Chim H, Jurczak M, Camporez J, et al.
Mol Cell
. 2012 Nov;
48(6):900-13.
PMID: 23142079
Hepatic glucose production (HGP) maintains blood glucose levels during fasting but can also exacerbate diabetic hyperglycemia. HGP is dynamically controlled by a signaling/transcriptional network that regulates the expression/activity of gluconeogenic...
2.
Gerhart-Hines Z, Dominy Jr J, Blattler S, Jedrychowski M, Banks A, Lim J, et al.
Mol Cell
. 2011 Dec;
44(6):851-63.
PMID: 22195961
The NAD(+)-dependent deacetylase SIRT1 is an evolutionarily conserved metabolic sensor of the Sirtuin family that mediates homeostatic responses to certain physiological stresses such as nutrient restriction. Previous reports have implicated...
3.
Stipanuk M, Simmons C, Karplus P, Dominy Jr J
Amino Acids
. 2010 Mar;
41(1):91-102.
PMID: 20195658
Proteins in the cupin superfamily have a wide range of biological functions in archaea, bacteria and eukaryotes. Although proteins in the cupin superfamily show very low overall sequence similarity, they...
4.
Dominy Jr J, Lee Y, Gerhart-Hines Z, Puigserver P
Biochim Biophys Acta
. 2009 Dec;
1804(8):1676-83.
PMID: 20005308
Mammals possess an intricate regulatory system for controlling flux through fuel utilization pathways in response to the dietary availability of particular macronutrients. Under fasting conditions, for instance, mammals initiate a...
5.
Stipanuk M, Dominy Jr J, Ueki I, Hirschberger L
Curr Protoc Toxicol
. 2009 Nov;
38:6.15.1-6.15.25.
PMID: 19885389
Cysteine dioxygenase is an iron (Fe(2+))-dependent thiol dioxygenase that uses molecular oxygen to oxidize the sulfhydryl group of cysteine to generate 3-sulfinoalanine (commonly called cysteinesulfinic acid). Cysteine dioxygenase activity is...
6.
Simmons C, Krishnamoorthy K, Granett S, Schuller D, Dominy Jr J, Begley T, et al.
Biochemistry
. 2008 Oct;
47(44):11390-2.
PMID: 18847220
The common reactions of dioxygen, superoxide, and hydroperoxides with thiolates are thought to proceed via persulfenate intermediates, yet these have never been visualized. Here we report a 1.4 A resolution...
7.
Dominy Jr J, Hwang J, Guo S, Hirschberger L, Zhang S, Stipanuk M
J Biol Chem
. 2008 Mar;
283(18):12188-201.
PMID: 18308719
Cysteine dioxygenase (CDO) catalyzes the conversion of cysteine to cysteinesulfinic acid and is important in the regulation of intracellular cysteine levels in mammals and in the provision of oxidized cysteine...
8.
Lee J, Dominy Jr J, Sikalidis A, Hirschberger L, Wang W, Stipanuk M
Physiol Genomics
. 2008 Feb;
33(2):218-29.
PMID: 18285520
To further define genes that are differentially expressed during cysteine deprivation and to evaluate the roles of amino acid deprivation vs. oxidative stress in the response to cysteine deprivation, we...
9.
Dominy Jr J, Simmons C, Hirschberger L, Hwang J, Coloso R, Stipanuk M
J Biol Chem
. 2007 Jun;
282(35):25189-98.
PMID: 17581819
There are only two known thiol dioxygenase activities in mammals, and they are ascribed to the enzymes cysteine dioxygenase (CDO) and cysteamine (2-aminoethanethiol) dioxygenase (ADO). Although many studies have been...
10.
Dominy Jr J, Hwang J, Stipanuk M
Am J Physiol Endocrinol Metab
. 2007 Mar;
293(1):E62-9.
PMID: 17327371
Cysteine levels are carefully regulated in mammals to balance metabolic needs against the potential for cytotoxicity. It has been postulated that one of the major regulators of intracellular cysteine levels...