John D Sears
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Explore the profile of John D Sears including associated specialties, affiliations and a list of published articles.
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13
Citations
61
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Recent Articles
1.
Dickmander R, Lenarcic E, Sears J, Hale A, Moorman N
Proc Natl Acad Sci U S A
. 2025 Mar;
122(10):e2421155122.
PMID: 40035757
Viruses have evolved unique strategies to circumvent host control of protein synthesis and enable viral protein synthesis in the face of the host response. Defining the factors that regulate viral...
2.
Ghoshal A, Tse E, Hossain M, Asressu K, Merten E, Sears J, et al.
Sci Rep
. 2025 Mar;
15(1):7264.
PMID: 40025188
Chikungunya is a mosquito-borne viral disease that causes fever and severe joint pain for which there is no direct acting drug treatments. Vinyl sulfone SGC-NSP2PRO-1 (3) was identified as a...
3.
Ghoshal A, Tse E, Hossain M, Asressu K, Merten E, Sears J, et al.
Res Sq
. 2024 Nov;
PMID: 39606462
RA-0003022 () was identified as a high-quality covalent chemical probe for nsP2 cysteine protease (nsP2pro). Isoxazole covalently captured the active site C478 and inactivated the enzyme with a / ratio...
4.
Merten E, Sears J, Leisner T, Hardy P, Ghoshal A, Hossain M, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(42):e2409166121.
PMID: 39388272
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has been responsible for numerous large-scale outbreaks in the last twenty years. Currently, there are no FDA-approved therapeutics for any alphavirus infection....
5.
Ghoshal A, Asressu K, Hossain M, Brown P, Nandakumar M, Vala A, et al.
J Med Chem
. 2024 Sep;
67(18):16505-16532.
PMID: 39235978
Despite their widespread impact on human health, there are no approved drugs for combating alphavirus infections. The heterocyclic β-aminomethyl vinyl sulfone RA-0002034 () is a potent irreversible covalent inhibitor of...
6.
Ghoshal A, Asressu K, Hossain M, Brown P, Merten E, Sears J, et al.
bioRxiv
. 2024 Jun;
PMID: 38915519
Despite their widespread impact on human health there are no approved drugs for combating alphavirus infections. The heterocyclic β-aminomethyl vinyl sulfone RA-0002034 () is a potent irreversible covalent inhibitor of...
7.
Wei J, Mayberry C, Lv X, Hu F, Khan T, Logan N, et al.
Cancer Immunol Res
. 2024 May;
12(7):822-839.
PMID: 38739030
Cytotoxic T lymphocytes (CTL) are pivotal in combating cancer, yet their efficacy is often hindered by the immunosuppressive tumor microenvironment, resulting in CTL exhaustion. This study investigates the role of...
8.
Merten E, Sears J, Leisner T, Hardy P, Ghoshal A, Hossain M, et al.
bioRxiv
. 2024 Apr;
PMID: 38562906
Significance Statement: Chikungunya virus is one of the most prominent and widespread alphaviruses and has caused explosive outbreaks of arthritic disease. Currently, there are no FDA-approved drugs to treat disease...
9.
Wells A, Wilson J, Heuer S, Sears J, Wei J, Pandey R, et al.
PLoS One
. 2024 Mar;
19(3):e0299595.
PMID: 38451972
Objective: Glycolytic inhibition via 2-deoxy-D-glucose (2DG) has potential therapeutic benefits for a range of diseases, including cancer, epilepsy, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA), and COVID-19, but the...
10.
Wilson J, Wei J, Daamen A, Sears J, Bechtel E, Mayberry C, et al.
iScience
. 2023 Aug;
26(9):107487.
PMID: 37636066
Aberrant metabolic demand is observed in immune/inflammatory disorders, yet the role in pathogenesis remains unclear. Here, we discover that in lupus, activated B cells, including germinal center B (GCB) cells,...