John D Belcher
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Explore the profile of John D Belcher including associated specialties, affiliations and a list of published articles.
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59
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2345
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Recent Articles
1.
Beckman J, Zhang P, Nguyen J, Hebbel R, Vercellotti G, Belcher J
Front Immunol
. 2025 Jan;
15():1493904.
PMID: 39776915
Sickle cell disease (SCD) is a devastating hemolytic disease, marked by recurring bouts of painful vaso-occlusion, leading to tissue damage from ischemia/reperfusion pathophysiology. Central to this process are oxidative stress,...
2.
Argueta D, Tran H, Goel Y, Nguyen A, Nguyen J, Kiven S, et al.
Life Sci Alliance
. 2024 Sep;
7(11).
PMID: 39242155
Sickle cell disease (SCD) is the most common inherited monogenetic disorder. Chronic and acute pain are hallmark features of SCD involving neural and vascular injury and inflammation. Mast cells reside...
3.
Ivy Z, Belcher J, Khasabova I, Chen C, Juliette J, Abdulla F, et al.
Blood
. 2023 Sep;
142(22):1918-1927.
PMID: 37774369
Vaso-occlusive pain episodes (VOE) cause severe pain in patients with sickle cell disease (SCD). Vaso-occlusive events promote ischemia/reperfusion pathobiology that activates complement. We hypothesized that complement activation is linked to...
4.
Belcher J, Nataraja S, Abdulla F, Zhang P, Chen C, Nguyen J, et al.
Front Med (Lausanne)
. 2023 May;
10:1101501.
PMID: 37144034
In sickle cell disease (SCD), heme released during intravascular hemolysis promotes oxidative stress, inflammation, and vaso-occlusion. Conversely, free heme can also activate expression of antioxidant and globin genes. Heme binds...
5.
Sparkenbaugh E, Henderson M, Miller-Awe M, Abrams C, Ilich A, Trebak F, et al.
Blood
. 2023 Jan;
141(15):1871-1883.
PMID: 36706361
A hypercoagulable state, chronic inflammation, and increased risk of venous thrombosis and stroke are prominent features in patients with sickle cell disease (SCD). Coagulation factor XII (FXII) triggers activation of...
6.
An R, Man Y, Cheng K, Zhang T, Chen C, Wang F, et al.
Br J Haematol
. 2023 Jan;
201(3):552-563.
PMID: 36604837
Endothelial activation and sickle red blood cell (RBC) adhesion are central to the pathogenesis of sickle cell disease (SCD). Quantitatively, RBC-derived extracellular vesicles (REVs) are more abundant from SS RBCs...
7.
Khasabova I, Juliette J, Rogness V, Khasabov S, Golovko M, Golovko S, et al.
Blood
. 2022 Aug;
140(16):1826-1830.
PMID: 35960856
No abstract available.
8.
Belcher J, Nguyen J, Chen C, Abdulla F, Conglin R, Ivy Z, et al.
Transl Res
. 2022 Jul;
249:1-12.
PMID: 35878790
Patients with sickle cell disease (SCD) have ongoing hemolysis that promotes endothelial injury, complement activation, inflammation, vaso-occlusion, ischemia-reperfusion pathophysiology, and pain. Complement activation markers are increased in SCD in steady-state...
9.
Gentinetta T, Belcher J, Brugger-Verdon V, Adam J, Ruthsatz T, Bain J, et al.
J Clin Med
. 2022 Feb;
11(3).
PMID: 35160081
People living with sickle cell disease (SCD) face intermittent acute pain episodes due to vaso-occlusion primarily treated palliatively with opioids. Hemolysis of sickle erythrocytes promotes release of heme, which activates...
10.
Zhang P, Nguyen J, Abdulla F, Nelson A, Beckman J, Vercellotti G, et al.
Front Immunol
. 2021 Apr;
12:632709.
PMID: 33841413
Recent evidence indicates that hemolysis in sickle cell disease (SCD) promotes inflammation innate immune signaling through toll-like receptor 4 (TLR4). Free heme released by hemolyzed red blood cells can bind...