John Crosby
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Explore the profile of John Crosby including associated specialties, affiliations and a list of published articles.
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49
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629
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Recent Articles
1.
Phillips A, Winter A, Hooper C, Williams C, Crosby J, Willis C, et al.
Angew Chem Int Ed Engl
. 2024 Sep;
64(2):e202414165.
PMID: 39324406
The leinamycin family of polyketides are promising antitumor antibiotics, yet several aspects of their biosynthesis remain elusive. All leinamycin family members bear a sulfur-containing moiety which is essential for the...
2.
Winter A, de Courcy-Ireland F, Phillips A, Barker J, Bakar N, Akter N, et al.
Angew Chem Int Ed Engl
. 2024 Aug;
63(49):e202410502.
PMID: 39105412
The delineation of the complex biosynthesis of the potent antibiotic mupirocin, which consists of a mixture of pseudomonic acids (PAs) isolated from Pseudomonas fluorescens NCIMB 10586, presents significant challenges, and...
3.
Serapian S, Crosby J, Crump M, van der Kamp M
JACS Au
. 2022 May;
2(4):972-984.
PMID: 35557750
In type II polyketide synthases (PKSs), which typically biosynthesize several antibiotic and antitumor compounds, the substrate is a growing polyketide chain, shuttled between individual PKS enzymes, while covalently tethered to...
4.
Walker P, Williams C, Weir A, Wang L, Crosby J, Race P, et al.
Angew Chem Int Ed Engl
. 2019 Jul;
58(36):12446-12450.
PMID: 31294525
The presence of β-branches in the structure of polyketides that possess potent biological activity underpins the widespread importance of this structural feature. Kalimantacin is a polyketide antibiotic with selective activity...
5.
Ellis B, Milligan J, White A, Duong V, Altman P, Mohammed L, et al.
J Am Chem Soc
. 2018 Apr;
140(15):4961-4964.
PMID: 29620883
Polyketides are a large class of bioactive natural products with a wide range of structures and functions. Polyketides are biosynthesized by large, multidomain enzyme complexes termed polyketide synthases (PKSs). One...
6.
Harper M, Arthur C, Crosby J, Emmett E, Falconer R, Fensham-Smith A, et al.
J Am Chem Soc
. 2018 Mar;
140(12):4440-4445.
PMID: 29553258
Three-coordinate bipyridyl complexes of gold, [(κ-bipy)Au(η-CH)][NTf], are readily accessed by direct reaction of 2,2'-bipyridine (bipy), or its derivatives, with the homoleptic gold ethylene complex [Au(CH)][NTf]. The cheap and readily available...
7.
Jackson D, Shakya G, Patel A, Mohammed L, Vasilakis K, Wattana-Amorn P, et al.
ACS Chem Biol
. 2017 Nov;
13(1):141-151.
PMID: 29161022
Daunorubicin is a type II polyketide, one of a large class of polyaromatic natural products with anticancer, antibiotic, and antiviral activity. Type II polyketides are formed by the assembly of...
8.
Dong X, Bailey C, Williams C, Crosby J, Simpson T, Willis C, et al.
Chem Sci
. 2017 Sep;
7(3):1779-1785.
PMID: 28936328
Polyketides are secondary metabolites which display both valuable pharmaceutical and agrochemical properties. Biosynthesis is performed by polyketide synthases (PKSs), and the acyl carrier protein (ACP), a small acidic protein, that...
9.
Loveridge E, Jones C, Bull M, Moody S, Kahl M, Khan Z, et al.
J Bacteriol
. 2017 Apr;
199(13).
PMID: 28439036
ATCC 31433 is a Gram-negative bacterium, first isolated from Japanese soil samples, that produces the monobactam isosulfazecin and the β-lactam-potentiating bulgecins. To characterize the biosynthetic potential of ATCC 31433, its...
10.