Thomas J Simpson
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Explore the profile of Thomas J Simpson including associated specialties, affiliations and a list of published articles.
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88
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1553
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Recent Articles
1.
de Mattos-Shipley K, Simpson T
Nat Prod Rep
. 2024 Aug;
41(9):1456.
PMID: 39118492
Correction for 'The 'emodin family' of fungal natural products-amalgamating a century of research with recent genomics-based advances' by Kate M. J. de Mattos-Shipley , , 2023, , 174-201, https://doi.org/10.1039/D2NP00040G.
2.
Winter A, Khanizeman R, Barker-Mountford A, Devine A, Wang L, Song Z, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
135(47):e202312514.
PMID: 38515435
Mupirocin is a clinically important antibiotic produced by a -AT Type I polyketide synthase (PKS) in . The major bioactive metabolite, pseudomonic acid A (PA-A), is assembled on a tetrasubstituted...
3.
Winter A, Khanizeman R, Barker-Mountford A, Devine A, Wang L, Song Z, et al.
Angew Chem Int Ed Engl
. 2023 Sep;
62(47):e202312514.
PMID: 37768840
Mupirocin is a clinically important antibiotic produced by a trans-AT Type I polyketide synthase (PKS) in Pseudomonas fluorescens. The major bioactive metabolite, pseudomonic acid A (PA-A), is assembled on a...
4.
de Mattos-Shipley K, Simpson T
Nat Prod Rep
. 2022 Oct;
40(1):174-201.
PMID: 36222427
Covering: up to 2022A very large group of biosynthetically linked fungal secondary metabolites are formed the key intermediate emodin and its corresponding anthrone. The group includes anthraquinones such as chrysophanol...
5.
Geris R, Pinho M, Boffo E, Simpson T
J Nat Prod
. 2022 Sep;
85(9):2236-2250.
PMID: 36098709
This Review provides a critical analysis of the literature covering the naturally occurring partially reduced perylenequinones (PQs) from fungi without carbon substituents (which can be named class A perylenequinones) and...
6.
Dao T, Williams K, de Mattos-Shipley K, Song Z, Takebayashi Y, Simpson T, et al.
J Nat Prod
. 2022 Feb;
85(3):572-580.
PMID: 35170975
Three new polyketide-derived natural products, cladobotric acids G-I (-), and six known metabolites (, , -) were isolated from fermentation of the fungus sp. grown on rice. Their structures were...
7.
Wang L, Song Z, Race P, Spencer J, Simpson T, Crump M, et al.
Chem Sci
. 2021 Jun;
11(20):5221-5226.
PMID: 34122978
With growing understanding of the underlying pathways of polyketide biosynthesis, along with the continual expansion of the synthetic biology toolkit, it is becoming possible to rationally engineer and fine-tune the...
8.
de Mattos-Shipley K, Spencer C, Greco C, Heard D, OFlynn D, Dao T, et al.
Chem Sci
. 2021 Jun;
11(42):11570-11578.
PMID: 34094403
Maleidrides are a class of bioactive secondary metabolites unique to filamentous fungi, which contain one or more maleic anhydrides fused to a 7-, 8- or 9- membered carbocycle (named heptadrides,...
9.
Marshall J, de Mattos-Shipley K, Ghannam I, Munawar A, Killen J, Lazarus C, et al.
Org Biomol Chem
. 2020 Oct;
19(1):182-187.
PMID: 33107888
Fusarochromene isolated from the plant pathogenic fungus, Fusarium sacchari is closely related to a group of mycotoxins including fusarochromanone previously isolated from various Fusaria spp. Despite their assumed polyketide biogenesis,...
10.
Davies J, Bull F, Walker P, Weir A, Lavigne R, Masschelein J, et al.
Org Lett
. 2020 Aug;
22(16):6349-6353.
PMID: 32806153
The kalimantacins make up a family of hybrid polyketide-nonribosomal peptide-derived natural products that display potent and selective antibiotic activity against multidrug resistant strains of . Herein, we report the first...