John C Whitney
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Explore the profile of John C Whitney including associated specialties, affiliations and a list of published articles.
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50
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2085
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Recent Articles
1.
Lu Y, Schuller M, Bullen N, Mikolcevic P, Zonjic I, Raggiaschi R, et al.
Nucleic Acids Res
. 2025 Feb;
53(4).
PMID: 39970281
Nucleic acid ADP-ribosylation and its associated enzymes involved in catalysis and hydrolysis are widespread among all kingdoms of life. Yet, its roles in mammalian and bacterial physiology including inter-/intraspecies conflicts...
2.
Lu Y, Schuller M, Bullen N, Mikolcevic P, Zonjic I, Raggiaschi R, et al.
Nucleic Acids Res
. 2025 Feb;
53(4).
PMID: 39964479
Nucleic acid ADP-ribosylation and its associated enzymes involved in catalysis and hydrolysis are widespread among all kingdoms of life. Yet, its roles in mammalian and bacterial physiology including inter-/intraspecies conflicts...
3.
Sachar K, Kanarek K, Colautti J, Kim Y, Bosis E, Prehna G, et al.
J Biol Chem
. 2025 Jan;
301(3):108242.
PMID: 39880087
Type VI secretion systems (T6SSs) are dynamic protein nanomachines found in Gram-negative bacteria that deliver toxic effector proteins into target cells in a contact-dependent manner. Prior to secretion, many T6SS...
4.
Colautti J, Kelly S, Whitney J
Biochem J
. 2025 Jan;
482(1):1-15.
PMID: 39774785
Type VI secretion systems (T6SSs) are widespread bacterial protein secretion machines that inject toxic effector proteins into nearby cells, thus facilitating both bacterial competition and virulence. Pseudomonas aeruginosa encodes three...
5.
Colautti J, Tan H, Bullen N, Thang S, Hackenberger D, Doxey A, et al.
Nat Commun
. 2024 Nov;
15(1):10108.
PMID: 39572545
Type VI secretion systems (T6SSs) are macromolecular assemblies that deliver toxic effector proteins between adjacent bacteria. These effectors span a wide range of protein families that all lack canonical signal...
6.
Alexei A, Bullen N, Garrett S, Sychantha D, Whitney J
J Biol Chem
. 2024 Nov;
300(12):108007.
PMID: 39551144
The human gastrointestinal tract is a competitive environment inhabited by dense polymicrobial communities. Bacteroides, a genus of Gram-negative anaerobes, are prominent members of this ecological niche. Bacteroides spp. uses a...
7.
Bullen N, Johnson C, Andersen S, Arya G, Marotta S, Lee Y, et al.
Nat Commun
. 2024 Aug;
15(1):6955.
PMID: 39138193
The prevalence of multidrug resistant (MDR) bacterial infections continues to rise as the development of antibiotics needed to combat these infections remains stagnant. MDR enterococci are a major contributor to...
8.
Klein T, Shah P, Gkragkopoulou P, Grebenc D, Kim Y, Whitney J
Proc Natl Acad Sci U S A
. 2024 Jan;
121(3):e2312455121.
PMID: 38194450
Type VII secretion systems are membrane-embedded nanomachines used by Gram-positive bacteria to export effector proteins from the cytoplasm to the extracellular environment. Many of these effectors are polymorphic toxins comprised...
9.
Gonzalez-Magana A, Tascon I, Altuna-Alvarez J, Queralt-Martin M, Colautti J, Velazquez C, et al.
Nat Commun
. 2023 Nov;
14(1):7808.
PMID: 38016939
Bacterial competition is a significant driver of toxin polymorphism, which allows continual compensatory evolution between toxins and the resistance developed to overcome their activity. Bacterial Rearrangement hot spot (Rhs) proteins...
10.
Bullen N, Johnson C, Andersen S, Arya G, Marotta S, Lee Y, et al.
bioRxiv
. 2023 Nov;
PMID: 38014348
The prevalence of multidrug resistant (MDR) bacterial infections continues to rise as the development of antibiotics needed to combat these infections remains stagnant. MDR enterococci are a major contributor to...