Nathan P Bullen
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Explore the profile of Nathan P Bullen including associated specialties, affiliations and a list of published articles.
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11
Citations
242
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Recent Articles
1.
Lu Y, Schuller M, Bullen N, Mikolcevic P, Zonjic I, Raggiaschi R, et al.
Nucleic Acids Res
. 2025 Feb;
53(4).
PMID: 39970281
Nucleic acid ADP-ribosylation and its associated enzymes involved in catalysis and hydrolysis are widespread among all kingdoms of life. Yet, its roles in mammalian and bacterial physiology including inter-/intraspecies conflicts...
2.
Lu Y, Schuller M, Bullen N, Mikolcevic P, Zonjic I, Raggiaschi R, et al.
Nucleic Acids Res
. 2025 Feb;
53(4).
PMID: 39964479
Nucleic acid ADP-ribosylation and its associated enzymes involved in catalysis and hydrolysis are widespread among all kingdoms of life. Yet, its roles in mammalian and bacterial physiology including inter-/intraspecies conflicts...
3.
Bullen N, Whiteley A
Mol Cell
. 2024 Dec;
84(23):4480-4482.
PMID: 39642854
Bacteria often defend against phage infection by deploying NADase effectors to degrade cellular NAD, thereby halting both bacterial growth and phage replication. In a recent article in Nature, Osterman et ...
4.
Colautti J, Tan H, Bullen N, Thang S, Hackenberger D, Doxey A, et al.
Nat Commun
. 2024 Nov;
15(1):10108.
PMID: 39572545
Type VI secretion systems (T6SSs) are macromolecular assemblies that deliver toxic effector proteins between adjacent bacteria. These effectors span a wide range of protein families that all lack canonical signal...
5.
Alexei A, Bullen N, Garrett S, Sychantha D, Whitney J
J Biol Chem
. 2024 Nov;
300(12):108007.
PMID: 39551144
The human gastrointestinal tract is a competitive environment inhabited by dense polymicrobial communities. Bacteroides, a genus of Gram-negative anaerobes, are prominent members of this ecological niche. Bacteroides spp. uses a...
6.
Bullen N, Johnson C, Andersen S, Arya G, Marotta S, Lee Y, et al.
Nat Commun
. 2024 Aug;
15(1):6955.
PMID: 39138193
The prevalence of multidrug resistant (MDR) bacterial infections continues to rise as the development of antibiotics needed to combat these infections remains stagnant. MDR enterococci are a major contributor to...
7.
Bullen N, Johnson C, Andersen S, Arya G, Marotta S, Lee Y, et al.
bioRxiv
. 2023 Nov;
PMID: 38014348
The prevalence of multidrug resistant (MDR) bacterial infections continues to rise as the development of antibiotics needed to combat these infections remains stagnant. MDR enterococci are a major contributor to...
8.
Colautti J, Bullen N, Whitney J
Mol Microbiol
. 2022 Dec;
119(2):262-274.
PMID: 36577706
Type VI secretion systems (T6SSs) are cell envelope-spanning protein complexes that Gram-negative bacteria use to inject a diverse arsenal of antibacterial toxins into competitor cells. Recently, Wang et al. reported...
9.
Bullen N, Sychantha D, Thang S, Culviner P, Rudzite M, Ahmad S, et al.
Mol Cell
. 2022 Sep;
82(18):3484-3498.e11.
PMID: 36070765
ADP-ribosyltransferases (ARTs) were among the first identified bacterial virulence factors. Canonical ART toxins are delivered into host cells where they modify essential proteins, thereby inactivating cellular processes and promoting pathogenesis....
10.
Ahmad S, Tsang K, Sachar K, Quentin D, Tashin T, Bullen N, et al.
Elife
. 2020 Dec;
9.
PMID: 33320089
Type VI secretion systems (T6SSs) deliver antibacterial effector proteins between neighboring bacteria. Many effectors harbor N-terminal ransembrane omains (TMDs) implicated in effector translocation across target cell membranes. However, the distribution...