John C Marioni
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Explore the profile of John C Marioni including associated specialties, affiliations and a list of published articles.
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163
Citations
21132
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Recent Articles
21.
Ton M, Keitley D, Theeuwes B, Guibentif C, Ahnfelt-Ronne J, Andreassen T, et al.
Nat Cell Biol
. 2023 Jun;
25(7):1061-1072.
PMID: 37322291
Traditionally, the mouse has been the favoured vertebrate model for biomedical research, due to its experimental and genetic tractability. However, non-rodent embryological studies highlight that many aspects of early mouse...
22.
Kumasaka N, Rostom R, Huang N, Polanski K, Meyer K, Patel S, et al.
Nat Genet
. 2023 Jun;
55(6):1066-1075.
PMID: 37308670
Common genetic variants across individuals modulate the cellular response to pathogens and are implicated in diverse immune pathologies, yet how they dynamically alter the response upon infection is not well...
23.
Ghazanfar S, Guibentif C, Marioni J
Nat Biotechnol
. 2023 May;
42(2):284-292.
PMID: 37231260
Currently available single-cell omics technologies capture many unique features with different biological information content. Data integration aims to place cells, captured with different technologies, onto a common embedding to facilitate...
24.
Castillo-Venzor A, Penfold C, Morgan M, Tang W, Kobayashi T, Wong F, et al.
Life Sci Alliance
. 2023 May;
6(8).
PMID: 37217306
Human germline-soma segregation occurs during weeks 2-3 in gastrulating embryos. Although direct studies are hindered, here, we investigate the dynamics of human primordial germ cell (PGCs) specification using in vitro...
25.
Lim K, Donovan A, Tang W, Sun D, He P, Pett J, et al.
Cell Stem Cell
. 2022 Dec;
30(1):20-37.e9.
PMID: 36493780
Variation in lung alveolar development is strongly linked to disease susceptibility. However, underlying cellular and molecular mechanisms are difficult to study in humans. We have identified an alveolar-fated epithelial progenitor...
26.
He P, Lim K, Sun D, Pett J, Jeng Q, Polanski K, et al.
Cell
. 2022 Dec;
185(25):4841-4860.e25.
PMID: 36493756
We present a multiomic cell atlas of human lung development that combines single-cell RNA and ATAC sequencing, high-throughput spatial transcriptomics, and single-cell imaging. Coupling single-cell methods with spatial analysis has...
27.
Pantazis C, Yang A, Lara E, McDonough J, Blauwendraat C, Peng L, et al.
Cell Stem Cell
. 2022 Dec;
29(12):1685-1702.e22.
PMID: 36459969
Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying development and disease, but the considerable phenotypic variation between lines makes it challenging to replicate key findings...
28.
Clark S, Argelaguet R, Lohoff T, Krueger F, Drage D, Gottgens B, et al.
Genome Biol
. 2022 Sep;
23(1):202.
PMID: 36163261
Background: Perturbation of DNA methyltransferases (DNMTs) and of the active DNA demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases results in severe developmental defects and embryonic lethality. Dynamic control of...
29.
Sun D, Llora Batlle O, van den Ameele J, Thomas J, He P, Lim K, et al.
EMBO J
. 2022 Sep;
41(21):e111338.
PMID: 36121125
The balance between self-renewal and differentiation in human foetal lung epithelial progenitors controls the size and function of the adult organ. Moreover, progenitor cell gene regulation networks are employed by...
30.
CellRegMap: a statistical framework for mapping context-specific regulatory variants using scRNA-seq
Cuomo A, Heinen T, Vagiaki D, Horta D, Marioni J, Stegle O
Mol Syst Biol
. 2022 Aug;
18(8):e10663.
PMID: 35972065
Single-cell RNA sequencing (scRNA-seq) enables characterizing the cellular heterogeneity in human tissues. Recent technological advances have enabled the first population-scale scRNA-seq studies in hundreds of individuals, allowing to assay genetic...