John A Frangos
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Explore the profile of John A Frangos including associated specialties, affiliations and a list of published articles.
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66
Citations
1673
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Recent Articles
1.
Furuhashi K, Kakiuchi M, Ueda R, Oda H, Ummarino S, Ebralidze A, et al.
Nature
. 2025 Jan;
638(8049):206-215.
PMID: 39743593
Stem cells reside in specialized microenvironments, termed niches, at several different locations in tissues. The differential functions of heterogeneous stem cells and niches are important given the increasing clinical applications...
2.
Dela Paz N, Frangos J
Am J Physiol Cell Physiol
. 2019 Feb;
316(5):C741-C752.
PMID: 30811222
Endothelial cell (EC) mechanochemical transduction is the process by which mechanical stimuli are sensed by ECs and transduced into biochemical signals and ultimately into physiological responses. Identifying the mechanosensor/mechanochemical transducer(s)...
3.
Ong P, Moreira A, Daniel-Ribeiro C, Frangos J, Carvalho L
Sci Rep
. 2018 Oct;
8(1):15957.
PMID: 30374028
Vascular dysfunction associated with low nitric oxide (NO) biavailability and low plasma L-arginine levels is observed in both human and experimental cerebral malaria (ECM). In ECM, cerebrovascular constriction results in...
4.
Dela Paz N, Frangos J
Biochem Biophys Res Commun
. 2018 Feb;
497(1):220-225.
PMID: 29428723
Piezo1 is a mechanosensitive cation channel that is activated by shear stress in endothelial cells (ECs). It has been shown to mediate shear-induced EC responses, including increased calcium influx, and...
5.
Dela Paz N, Melchior B, Frangos J
Am J Physiol Cell Physiol
. 2017 Feb;
312(4):C428-C437.
PMID: 28148497
Mechanochemical signal transduction occurs when mechanical forces, such as fluid shear stress, are converted into biochemical responses within the cell. The molecular mechanisms by which endothelial cells (ECs) sense/transduce shear...
6.
Russell-Puleri S, Dela Paz N, Adams D, Chattopadhyay M, Cancel L, Ebong E, et al.
Am J Physiol Heart Circ Physiol
. 2016 Dec;
312(3):H485-H500.
PMID: 28011582
Vascular endothelial cells play an important role in the regulation of vascular function in response to mechanical stimuli in both healthy and diseased states. Prostaglandin I (PGI) is an important...
7.
Bertinaria M, Orjuela-Sanchez P, Marini E, Guglielmo S, Hofer A, Martins Y, et al.
J Med Chem
. 2015 Sep;
58(19):7895-9.
PMID: 26367273
Hybrid products in which the dihydroartemisinin scaffold is combined with NO-donor furoxan and NONOate moieties have been synthesized and studied as potential tools for the treatment of cerebral malaria (CM)....
8.
Kalyanaraman H, Schwappacher R, Joshua J, Zhuang S, Scott B, Klos M, et al.
Sci Signal
. 2014 May;
7(326):ra48.
PMID: 24847117
Thyroid hormone (TH) is essential for vertebrate development and the homeostasis of most adult tissues, including bone. TH stimulates target gene expression through the nuclear thyroid receptors TRα and TRβ;...
9.
Dela Paz N, Melchior B, Shayo F, Frangos J
J Biol Chem
. 2014 Feb;
289(11):7413-24.
PMID: 24497640
The endothelial cell-cell junction has emerged as a major cell signaling structure that responds to shear stress by eliciting the activation of signaling pathways. Platelet endothelial cell adhesion molecule-1 (PECAM-1)...
10.
Hong S, Dvorak-Ewell M, Stevens H, Barish G, Castro G, Nofsinger R, et al.
Proc Natl Acad Sci U S A
. 2013 Nov;
110(47):18820-5.
PMID: 24191050
Molecular targeting of the two receptor interaction domains of the epigenetic repressor silencing mediator of retinoid and thyroid hormone receptors (SMRT(mRID)) produced a transplantable skeletal syndrome that reduced radial bone...