Johannes Raffler
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Explore the profile of Johannes Raffler including associated specialties, affiliations and a list of published articles.
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31
Citations
2235
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Recent Articles
11.
Pietzner M, Wheeler E, Carrasco-Zanini J, Raffler J, Kerrison N, Oerton E, et al.
Nat Commun
. 2021 Feb;
12(1):845.
PMID: 33531486
No abstract available.
12.
Lotta L, Pietzner M, Stewart I, Wittemans L, Li C, Bonelli R, et al.
Nat Genet
. 2021 Jan;
53(1):54-64.
PMID: 33414548
In cross-platform analyses of 174 metabolites, we identify 499 associations (P < 4.9 × 10) characterized by pleiotropy, allelic heterogeneity, large and nonlinear effects and enrichment for nonsynonymous variation. We...
13.
Pietzner M, Wheeler E, Carrasco-Zanini J, Raffler J, Kerrison N, Oerton E, et al.
Nat Commun
. 2020 Dec;
11(1):6397.
PMID: 33328453
Understanding the genetic architecture of host proteins interacting with SARS-CoV-2 or mediating the maladaptive host response to COVID-19 can help to identify new or repurpose existing drugs targeting those proteins....
14.
Pietzner M, Wheeler E, Carrasco-Zanini J, Raffler J, Kerrison N, Oerton E, et al.
bioRxiv
. 2020 Jul;
PMID: 32637948
Strategies to develop therapeutics for SARS-CoV-2 infection may be informed by experimental identification of viral-host protein interactions in cellular assays and measurement of host response proteins in COVID-19 patients. Identification...
15.
Nag A, Kurushima Y, Bowyer R, Wells P, Weiss S, Pietzner M, et al.
Hum Mol Genet
. 2020 Jan;
29(5):864-875.
PMID: 31960908
Saliva, as a biofluid, is inexpensive and non-invasive to obtain, and provides a vital tool to investigate oral health and its interaction with systemic health conditions. There is growing interest...
16.
Schlosser P, Li Y, Sekula P, Raffler J, Grundner-Culemann F, Pietzner M, et al.
Nat Genet
. 2020 Jan;
52(2):167-176.
PMID: 31959995
The kidneys integrate information from continuous systemic processes related to the absorption, distribution, metabolism and excretion (ADME) of metabolites. To identify underlying molecular mechanisms, we performed genome-wide association studies of...
17.
Do K, Wahl S, Raffler J, Molnos S, Laimighofer M, Adamski J, et al.
Metabolomics
. 2019 Mar;
14(10):128.
PMID: 30830398
Background: Untargeted mass spectrometry (MS)-based metabolomics data often contain missing values that reduce statistical power and can introduce bias in biomedical studies. However, a systematic assessment of the various sources...
18.
Hamad S, Adornetto G, Naveja J, Ravindranath A, Raffler J, Campillos M
Bioinformatics
. 2018 Sep;
35(7):1239-1240.
PMID: 30169615
Motivation: The identification of protein targets of novel compounds is essential to understand compounds' mechanisms of action leading to biological effects. Experimental methods to determine these protein targets are usually...
19.
Kottgen A, Raffler J, Sekula P, Kastenmuller G
Semin Nephrol
. 2018 Apr;
38(2):151-174.
PMID: 29602398
Metabolites are small molecules that are intermediates or products of metabolism, many of which are freely filtered by the kidneys. In addition, the kidneys have a central role in metabolite...
20.
Rueedi R, Mallol R, Raffler J, Lamparter D, Friedrich N, Vollenweider P, et al.
PLoS Comput Biol
. 2017 Dec;
13(12):e1005839.
PMID: 29194434
A metabolome-wide genome-wide association study (mGWAS) aims to discover the effects of genetic variants on metabolome phenotypes. Most mGWASes use as phenotypes concentrations of limited sets of metabolites that can...