Johannes H G M van Beek
Overview
Explore the profile of Johannes H G M van Beek including associated specialties, affiliations and a list of published articles.
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26
Citations
746
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Recent Articles
1.
van Beek J
F1000Res
. 2019 Feb;
7:1177.
PMID: 30755789
: Tumor cells often show altered metabolism which supports uncontrolled proliferation. A classic example is the Warburg effect: high glucose uptake and lactate production despite sufficient oxygen supply. Remarkably, tumor...
2.
Supandi F, van Beek J
PLoS One
. 2018 Sep;
13(9):e0203687.
PMID: 30208076
Background: Parkinson's disease is a widespread neurodegenerative disorder which affects brain metabolism. Although changes in gene expression during disease are often measured, it is difficult to predict metabolic fluxes from...
3.
van Beek J, Kirkwood T, Bassingthwaighte J
Interface Focus
. 2016 Apr;
6(2):20150079.
PMID: 27051508
Ageing and lifespan are strongly affected by metabolism. The maximal possible uptake of oxygen is not only a good predictor of performance in endurance sports, but also of life expectancy....
4.
Alders D, Groeneveld A, Binsl T, van Beek J
Am J Physiol Heart Circ Physiol
. 2015 Sep;
309(10):H1708-19.
PMID: 26408545
In normal hearts, myocardial perfusion is fairly well matched to regional metabolic demand, although both are distributed heterogeneously. Nonuniform regional metabolic vulnerability during coronary stenosis would help to explain nonuniform...
5.
Gavai A, Supandi F, Hettling H, Murrell P, Leunissen J, van Beek J
PLoS One
. 2015 Mar;
10(3):e0119016.
PMID: 25806817
Predicting the distribution of metabolic fluxes in biochemical networks is of major interest in systems biology. Several databases provide metabolic reconstructions for different organisms. Software to analyze flux distributions exists,...
6.
Hunter P, Chapman T, Coveney P, de Bono B, Diaz V, Fenner J, et al.
Interface Focus
. 2014 Jan;
3(2):20130004.
PMID: 24427536
European funding under Framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for 5 years. The VPH Network of Excellence (NoE) has been set...
7.
Reijnders C, van Essen H, van Rens B, van Beek J, Ylstra B, Blankenstein M, et al.
PLoS One
. 2013 Nov;
8(11):e79672.
PMID: 24255709
Skeletal integrity in humans and animals is maintained by daily mechanical loading. It has been widely accepted that osteocytes function as mechanosensors. Many biochemical signaling molecules are involved in the...
8.
Hettling H, Alders D, Heringa J, Binsl T, Groeneveld A, van Beek J
BMC Syst Biol
. 2013 Aug;
7:82.
PMID: 23965343
Background: The aerobic energy metabolism of cardiac muscle cells is of major importance for the contractile function of the heart. Because energy metabolism is very heterogeneously distributed in heart tissue,...
9.
Thiele I, Swainston N, Fleming R, Hoppe A, Sahoo S, Aurich M, et al.
Nat Biotechnol
. 2013 Mar;
31(5):419-25.
PMID: 23455439
Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the...
10.
Schepers H, van Beek J, Bassingthwaighte J
IEEE Eng Med Biol Mag
. 2012 Oct;
11(2):57-64.
PMID: 23024449
No abstract available.