David J C Alders
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Explore the profile of David J C Alders including associated specialties, affiliations and a list of published articles.
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6
Citations
16
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Recent Articles
1.
Alders D, Groeneveld A, Binsl T, van Beek J
Am J Physiol Heart Circ Physiol
. 2015 Sep;
309(10):H1708-19.
PMID: 26408545
In normal hearts, myocardial perfusion is fairly well matched to regional metabolic demand, although both are distributed heterogeneously. Nonuniform regional metabolic vulnerability during coronary stenosis would help to explain nonuniform...
2.
Hettling H, Alders D, Heringa J, Binsl T, Groeneveld A, van Beek J
BMC Syst Biol
. 2013 Aug;
7:82.
PMID: 23965343
Background: The aerobic energy metabolism of cardiac muscle cells is of major importance for the contractile function of the heart. Because energy metabolism is very heterogeneously distributed in heart tissue,...
3.
Alders D, Groeneveld A, Binsl T, de Kanter F, van Beek J
Am J Physiol Heart Circ Physiol
. 2011 Feb;
300(4):H1459-66.
PMID: 21297021
Heterogeneity of regional coronary blood flow is caused in part by heterogeneity in O(2) demand in the normal heart. We investigated whether myocardial O(2) supply/demand mismatching is associated with the...
4.
Binsl T, Alders D, Heringa J, Groeneveld A, van Beek J
Bioinformatics
. 2010 Jan;
26(5):653-60.
PMID: 20097912
Motivation: Quantitative determination of metabolic fluxes in single tissue biopsies is difficult. We report a novel analysis approach and software package for in vivo flux quantification using stable isotope labeling....
5.
Alders D, Cornelussen R, Prinzen F, Specht P, Noble M, Drake-Holland A, et al.
Exp Physiol
. 2007 Feb;
92(3):541-8.
PMID: 17303649
Myocardial blood flow and oxygen consumption are heterogeneously distributed. Perfusion and myocardial oxygen consumption are closely correlated in the normal heart. It is unknown how this metabolism-perfusion relation is influenced...
6.
Alders D, Groeneveld A, de Kanter F, van Beek J
Am J Physiol Heart Circ Physiol
. 2004 May;
287(3):H1353-61.
PMID: 15142850
Myocardial blood flow is unevenly distributed, but the cause of this heterogeneity is unknown. Heterogeneous blood flow may reflect heterogeneity of oxygen demand. The aim of the present study was...