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Johannes Eichner

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Articles 24
Citations 372
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Recent Articles
1.
Gao Y, Yurkovich J, Seo S, Kabimoldayev I, Drager A, Chen K, et al.
Nucleic Acids Res . 2018 Aug; 46(20):10682-10696. PMID: 30137486
Transcriptional regulation enables cells to respond to environmental changes. Of the estimated 304 candidate transcription factors (TFs) in Escherichia coli K-12 MG1655, 185 have been experimentally identified, but ChIP methods...
2.
Lempiainen H, Braenne I, Michoel T, Tragante V, Vilne B, Webb T, et al.
Sci Rep . 2018 Feb; 8(1):3434. PMID: 29467471
Genome-wide association studies (GWAS) have identified over two hundred chromosomal loci that modulate risk of coronary artery disease (CAD). The genes affected by variants at these loci are largely unknown...
3.
Nejabat M, Riegler T, Reitinger T, Subosits S, Romer M, Eichner J, et al.
Arch Toxicol . 2017 Dec; 92(2):953-966. PMID: 29270806
Many frequently prescribed drugs are non-genotoxic carcinogens (NGC) in rodent liver. Their mode of action and health risks for humans remain to be elucidated. Here, we investigated the impact of...
4.
Widschwendter M, Zikan M, Wahl B, Lempiainen H, Paprotka T, Evans I, et al.
Genome Med . 2017 Dec; 9(1):116. PMID: 29268796
Background: Despite a myriad of attempts in the last three decades to diagnose ovarian cancer (OC) earlier, this clinical aim still remains a significant challenge. Aberrant methylation patterns of linked...
5.
Widschwendter M, Evans I, Jones A, Ghazali S, Reisel D, Ryan A, et al.
Genome Med . 2017 Dec; 9(1):115. PMID: 29268762
Background: Monitoring treatment and early detection of fatal breast cancer (BC) remains a major unmet need. Aberrant circulating DNA methylation (DNAme) patterns are likely to provide a highly specific cancer...
6.
Romer M, Eichner J, Drager A, Wrzodek C, Wrzodek F, Zell A
PLoS One . 2016 Feb; 11(2):e0149263. PMID: 26882475
Bioinformatics analysis has become an integral part of research in biology. However, installation and use of scientific software can be difficult and often requires technical expert knowledge. Reasons are dependencies...
7.
Drager A, Zielinski D, Keller R, Rall M, Eichner J, Palsson B, et al.
BMC Syst Biol . 2015 Oct; 9:68. PMID: 26452770
Background: The size and complexity of published biochemical network reconstructions are steadily increasing, expanding the potential scale of derived computational models. However, the construction of large biochemical network models is...
8.
Riegler T, Nejabat M, Eichner J, Stiebellehner M, Subosits S, Bilban M, et al.
Carcinogenesis . 2015 Sep; 36(12):1521-30. PMID: 26378027
Many environmental pollutants and drugs, including steroid hormones, hypolipidemics and antiepileptics, are non-genotoxic carcinogens (NGC) in rodent liver. The mechanism of action and the risk for human health are still...
9.
Rodriguez N, Thomas A, Watanabe L, Vazirabad I, Kofia V, Gomez H, et al.
Bioinformatics . 2015 Jun; 31(20):3383-6. PMID: 26079347
Unlabelled: JSBML, the official pure Java programming library for the Systems Biology Markup Language (SBML) format, has evolved with the advent of different modeling formalisms in systems biology and their...
10.
Romer M, Backert L, Eichner J, Zell A
Int J Mol Sci . 2014 Oct; 15(10):19037-55. PMID: 25338045
We present a new tool for hepatocarcinogenicity evaluation of drug candidates in rodents. ToxDBScan is a web tool offering quick and easy similarity screening of new drug candidates against two...