Johan W M Heemskerk
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Explore the profile of Johan W M Heemskerk including associated specialties, affiliations and a list of published articles.
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226
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5301
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Recent Articles
11.
Provenzale I, Solari F, Schonichen C, Brouns S, Fernandez D, Kuijpers M, et al.
FASEB J
. 2024 Feb;
38(4):e23468.
PMID: 38334433
The endothelial regulation of platelet activity is incompletely understood. Here we describe novel approaches to find molecular pathways implicated on the platelet-endothelium interaction. Using high-shear whole-blood microfluidics, employing coagulant or...
12.
Jooss N, Diender M, Fernandez D, Huang J, Heubel-Moenen F, van der Veer A, et al.
Cell Mol Life Sci
. 2024 Jan;
81(1):44.
PMID: 38236412
The platelet receptors, glycoprotein VI (GPVI) and integrin α2β1 jointly control collagen-dependent thrombus formation via protein tyrosine kinases. It is unresolved to which extent the ITIM (immunoreceptor tyrosine-based inhibitory motif)...
13.
Provenzale I, de Simone I, Gibbins J, Heemskerk J, van der Meijden P, Jones C
Int J Mol Sci
. 2023 Sep;
24(17).
PMID: 37686158
Proteoglycans form a heterogeneous family of proteins with covalently bound sulfated glycosaminoglycans. The extracellular matrix proteoglycan perlecan has been proposed to bind to the platelet- and megakaryocyte-specific receptor G6bB, co-regulating...
14.
Sun S, Campello E, Zou J, Konings J, Huskens D, Wan J, et al.
Blood Adv
. 2023 Aug;
7(21):6717-6731.
PMID: 37648671
Red blood cells (RBCs) and platelets contribute to the coagulation capacity in bleeding and thrombotic disorders. The thrombin generation (TG) process is considered to reflect the interactions between plasma coagulation...
15.
Verdier H, Thomas P, Batista J, Kempster C, McKinney H, Gleadall N, et al.
Blood
. 2023 Aug;
142(22):1895-1908.
PMID: 37647652
Genetic studies of platelet reactivity (PR) phenotypes may identify novel antiplatelet drug targets. However, such studies have been limited by small sample sizes (n < 5000) because of the complexity...
16.
Schonichen C, Montague S, Brouns S, Burston J, Cosemans J, Jurk K, et al.
Arterioscler Thromb Vasc Biol
. 2023 Jul;
43(9):1700-1712.
PMID: 37409530
Background: Platelets and neutrophils are the first blood cells accumulating at sites of arterial thrombus formation, and both cell types contribute to the pathology of thrombotic events. We aimed to...
17.
Fernandez D, Provenzale I, Canault M, Fels S, Lenz A, Andresen F, et al.
Blood Adv
. 2023 Jun;
7(20):6163-6177.
PMID: 37389831
Linking the genetic background of patients with bleeding diathesis and altered platelet function remains challenging. We aimed to assess how a multiparameter microspot-based measurement of thrombus formation under flow can...
18.
Gotru S, Mammadova-Bach E, Sogkas G, Schuhmann M, Schmitt K, Kraft P, et al.
Arterioscler Thromb Vasc Biol
. 2023 Jun;
43(8):1494-1509.
PMID: 37381987
Background: MAGT1 (magnesium transporter 1) is a subunit of the oligosaccharide protein complex with thiol-disulfide oxidoreductase activity, supporting the process of N-glycosylation. MAGT1 deficiency was detected in human patients with...
19.
Huang J, Heemskerk J, Swieringa F
Platelets
. 2023 Jun;
34(1):2224454.
PMID: 37313659
The anucleate human platelets contain a broad pattern of mRNAs and other RNA transcripts. The high quantitative similarity of mRNAs in megakaryocytes and platelets from different sources points to a...
20.
Fernandez D, Diender M, Hermida-Nogueira L, Huang J, Veiras S, Henskens Y, et al.
Thromb Res
. 2023 Jun;
228:105-116.
PMID: 37302266
Introduction: The protein tyrosine phosphatase SHP2 (PTPN11) is a negative regulator of glycoprotein VI (GPVI)-induced platelet signal under certain conditions. Clinical trials with derivatives of the allosteric drug SHP099, inhibiting...