Johan Fransson
Overview
Explore the profile of Johan Fransson including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
15
Citations
229
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Hallett R, Bonfill-Teixidor E, Iurlaro R, Arias A, Raman S, Bayliss P, et al.
Clin Cancer Res
. 2022 Nov;
29(4):791-804.
PMID: 36441800
Purpose: Leukemia inhibitory factor (LIF) is a multifunctional cytokine with numerous reported roles in cancer and is thought to drive tumor development and progression. Characterization of LIF and clinical-stage LIF...
2.
Merico D, Spickett C, OHara M, Kakaradov B, Deshwar A, Fradkin P, et al.
NPJ Genom Med
. 2020 Apr;
5:16.
PMID: 32284880
Wilson disease is a recessive genetic disorder caused by pathogenic loss-of-function variants in the gene. It is characterized by disrupted copper homeostasis resulting in liver disease and/or neurological abnormalities. The...
3.
Raman S, Beilschmidt M, To M, Lin K, Lui F, Jmeian Y, et al.
Proc Natl Acad Sci U S A
. 2019 Mar;
116(14):6812-6817.
PMID: 30894493
Aberrant activation of Wnt/β-catenin signaling occurs frequently in cancer. However, therapeutic targeting of this pathway is complicated by the role of Wnt in stem cell maintenance and tissue homeostasis. Here,...
4.
Jetha A, Thorsteinson N, Jmeian Y, Jeganathan A, Giblin P, Fransson J
MAbs
. 2018 Aug;
10(6):890-900.
PMID: 30110240
Monoclonal antibody (mAb) candidates from high-throughput screening or binding affinity optimization often contain mutations leading to liabilities for further development of the antibody, such as aggregation-prone regions and lack of...
5.
Teplyakov A, Obmolova G, Malia T, Raghunathan G, Martinez C, Fransson J, et al.
MAbs
. 2017 Dec;
10(2):269-277.
PMID: 29283291
Murine antibody 10H10 raised against human tissue factor is unique in that it blocks the signaling pathway, and thus inhibits angiogenesis and tumor growth without interfering with coagulation. As a...
6.
Almagro J, Raghunathan G, Beil E, Janecki D, Chen Q, Dinh T, et al.
J Mol Recognit
. 2012 Mar;
25(3):125-35.
PMID: 22407976
Disulfide bridges are common in the antigen-binding site from sharks (new antigen receptor) and camels (single variable heavy-chain domain, VHH), in which they confer both structural diversity and domain stability....
7.
Fransson J, Teplyakov A, Raghunathan G, Chi E, Cordier W, Dinh T, et al.
J Mol Biol
. 2010 Mar;
398(2):214-31.
PMID: 20226193
Humanization of a potent neutralizing mouse anti-human IL-13 antibody (m836) using a method called human framework adaptation (HFA) is reported. HFA consists of two steps: human framework selection (HFS) and...
8.
Persson O, Salford L, Fransson J, Widegren B, Borrebaeck C, Holmqvist B
J Neurooncol
. 2009 Oct;
97(2):207-15.
PMID: 19809793
Antibodies specifically targeting tumor-associated antigens have proved to be important tools in the treatment of human cancer. A desirable target antigen should be unique to tumor cells, abundantly expressed, and...
9.
Fransson J, Borrebaeck C
Methods Mol Biol
. 2008 Dec;
480:113-27.
PMID: 19085115
Macromolecular delivery systems require high target cell specificity and efficient intracellular uptake. Monoclonal antibodies (mAbs) have been shown to successfully meet these needs and should, due to their biological nature...
10.
Ortega-Paino E, Fransson J, Ek S, Borrebaeck C
Blood
. 2007 Nov;
111(3):1617-24.
PMID: 18024791
Mantle cell lymphoma (MCL) is a non-Hodgkin lymphoma with poor prognosis. Its hallmark is the translocation t(11:14)q (13;32), leading to overexpression of cyclin D1, a positive regulator of the cell...