Joel C Bornstein
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Explore the profile of Joel C Bornstein including associated specialties, affiliations and a list of published articles.
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87
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1860
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Recent Articles
1.
Herath M, Bornstein J, Hill-Yardin E, Franks A
ISME J
. 2025 Mar;
PMID: 40036582
The intestinal mucus layer protects the host from invading pathogens and is essential for maintaining a healthy mucosal microbial community. Alterations in the mucus layer and composition of mucus-residing microbiota...
2.
Leembruggen A, Yildiz G, Yildiz G, Hardee J, Stamp L, Bornstein J, et al.
Am J Physiol Gastrointest Liver Physiol
. 2025 Jan;
328(2):G145-G151.
PMID: 39763332
The circadian cycle is a fundamental biological rhythm that governs many physiological functions across nearly all living organisms. In the gastrointestinal tract, activities such as gut motility, hormone synthesis, and...
3.
Bornstein J
J Clin Invest
. 2024 Nov;
134(21).
PMID: 39484722
Loss of enteric neurons leading to long-term gastrointestinal dysfunction is common to many diseases, and the path to functional recovery is unclear. In this issue of the JCI, Janova et...
4.
Wang H, Barry K, Zaini A, Coakley G, Moyat M, Daunt C, et al.
PLoS Pathog
. 2024 Aug;
20(8):e1011766.
PMID: 39141685
Intestinal helminth infection triggers a type 2 immune response that promotes a 'weep-and sweep' response characterised by increased mucus secretion and intestinal hypermotility, which function to dislodge the worm from...
5.
Hosie S, Abo-Shaban T, Mou K, Balasuriya G, Mohsenipour M, Alamoudi M, et al.
Int J Mol Sci
. 2024 Jan;
25(2).
PMID: 38255906
Individuals with autism often experience gastrointestinal issues but the cause is unknown. Many gene mutations that modify neuronal synapse function are associated with autism and therefore may impact the enteric...
6.
Herath M, Cho E, Marklund U, Franks A, Bornstein J, Hill-Yardin E
Biomolecules
. 2023 Jul;
13(7).
PMID: 37509099
Mutations in the Neuroligin-3 () gene are implicated in autism spectrum disorder (ASD) and gastrointestinal (GI) dysfunction, but cellular expression in the enteric nervous system remains to be characterised. We...
7.
Leembruggen A, Lu Y, Wang H, Uzungil V, Renoir T, Hannan A, et al.
Biomolecules
. 2023 Jan;
13(1).
PMID: 36671524
Glutamate is the major excitatory neurotransmitter in the central nervous system, and there is evidence that Group-I metabotropic glutamate receptors (mGlu1 and mGlu5) have established roles in excitatory neurotransmission and...
8.
Sahakian L, McQuade R, Stavely R, Robinson A, Filippone R, Hassanzadeganroudsari M, et al.
Adv Exp Med Biol
. 2022 Dec;
1383:221-228.
PMID: 36587161
Enteric neuropathy underlies long-term gastrointestinal (GI) dysfunction associated with several pathological conditions. Our previous studies have demonstrated that structural and functional changes in the enteric nervous system (ENS) result in...
9.
Leembruggen A, Stamp L, Bornstein J, Hao M
Adv Exp Med Biol
. 2022 Dec;
1383:191-203.
PMID: 36587158
With the earth's 24-h rotation cycle, physiological function fluctuates in both diurnal and nocturnal animals, thereby ensuring optimal functioning of the body. The main regulator of circadian rhythm is the...
10.
Stavely R, Sahakian L, Filippone R, Stojanovska V, Bornstein J, Sakkal S, et al.
Biomolecules
. 2022 Dec;
12(12).
PMID: 36551259
High-mobility group box 1 (HMGB1) is a damage-associated molecular pattern released by dying cells to stimulate the immune response. During cell death, HMGB1 is translocated from the nucleus to the...