Joe J Harrison
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Explore the profile of Joe J Harrison including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Whitfield G, Marmont L, Ostaszewski A, Rich J, Whitney J, Parsek M, et al.
J Bacteriol
. 2020 Jan;
202(8).
PMID: 31988082
The Pel polysaccharide is a structural component of the extracellular matrix of biofilms. Recent analyses suggest that Pel production proceeds via a synthase-dependent polysaccharide secretion pathway, which in Gram-negative bacteria...
12.
Morgan S, Lippman S, Bautista G, Harrison J, Harding C, Gallagher L, et al.
PLoS Pathog
. 2019 Mar;
15(3):e1007511.
PMID: 30893371
While much is known about acute infection pathogenesis, the understanding of chronic infections has lagged. Here we sought to identify the genes and functions that mediate fitness of the pathogen...
13.
Tseng B, Reichhardt C, Merrihew G, Araujo-Hernandez S, Harrison J, MacCoss M, et al.
mBio
. 2018 Apr;
9(2).
PMID: 29636440
produces an extracellular biofilm matrix that consists of nucleic acids, exopolysaccharides, lipid vesicles, and proteins. In general, the protein component of the biofilm matrix is poorly defined and understudied relative...
14.
Jorth P, McLean K, Ratjen A, Secor P, Bautista G, Ravishankar S, et al.
mBio
. 2017 Nov;
8(5).
PMID: 29089424
While much attention has been focused on acquired antibiotic resistance genes, chromosomal mutations may be most important in chronic infections where isolated, persistently infecting lineages experience repeated antibiotic exposure. Here,...
15.
Marmont L, Whitfield G, Rich J, Yip P, Giesbrecht L, Stremick C, et al.
J Biol Chem
. 2017 Oct;
292(47):19411-19422.
PMID: 28972168
The pellicle (PEL) polysaccharide is synthesized by the opportunistic pathogen and is an important biofilm constituent critical for bacterial virulence and persistence. PEL is a cationic polymer that promotes cell-cell...
16.
Eli D, Randall T, Almblad H, Harrison J, Banin E
Methods Mol Biol
. 2017 Sep;
1657:263-278.
PMID: 28889300
The second messenger, cyclic diguanylate (c-di-GMP), regulates a variety of bacterial cellular and social behaviors. A key determinant of c-di-GMP levels in cells is its degradation by c-di-GMP-specific phosphodiesterases (PDEs)....
17.
Marmont L, Rich J, Whitney J, Whitfield G, Almblad H, Robinson H, et al.
Proc Natl Acad Sci U S A
. 2017 Mar;
114(11):2892-2897.
PMID: 28242707
Secreted polysaccharides are important functional and structural components of bacterial biofilms. The opportunistic pathogen produces the cationic exopolysaccharide Pel, which protects bacteria from aminoglycoside antibiotics and contributes to biofilm architecture...
18.
Beatty J, Akierman S, Motta J, Muise S, Workentine M, Harrison J, et al.
Int J Parasitol
. 2017 Feb;
47(6):311-326.
PMID: 28237889
Giardia duodenalis is a prevalent cause of acute diarrheal disease worldwide. However, recent outbreaks in Italy and Norway have revealed a link between giardiasis and the subsequent development of chronic...
19.
Hmelo L, Borlee B, Almblad H, Love M, Randall T, Tseng B, et al.
Nat Protoc
. 2015 Oct;
10(11):1820-41.
PMID: 26492139
Allelic exchange is an efficient method of bacterial genome engineering. This protocol describes the use of this technique to make gene knockouts and knock-ins, as well as single-nucleotide insertions, deletions...
20.
Freschi L, Jeukens J, Kukavica-Ibrulj I, Boyle B, Dupont M, Laroche J, et al.
Front Microbiol
. 2015 Oct;
6:1036.
PMID: 26483767
The International Pseudomonas aeruginosa Consortium is sequencing over 1000 genomes and building an analysis pipeline for the study of Pseudomonas genome evolution, antibiotic resistance and virulence genes. Metadata, including genomic...