Jochen Singer
Overview
Explore the profile of Jochen Singer including associated specialties, affiliations and a list of published articles.
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13
Citations
862
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Recent Articles
1.
Kuipers J, Singer J, Beerenwinkel N
Bioinformatics
. 2022 Aug;
38(20):4713-4719.
PMID: 36000873
Motivation: Tumours evolve as heterogeneous populations of cells, which may be distinguished by different genomic aberrations. The resulting intra-tumour heterogeneity plays an important role in cancer patient relapse and treatment...
2.
Dimitrakopoulos C, Hindupur S, Colombi M, Liko D, Ng C, Piscuoglio S, et al.
BMC Genomics
. 2021 Aug;
22(1):592.
PMID: 34348664
Background: Genetic aberrations in hepatocellular carcinoma (HCC) are well known, but the functional consequences of such aberrations remain poorly understood. Results: Here, we explored the effect of defined genetic changes...
3.
Moore A, Batavia A, Kuipers J, Singer J, Burcklen E, Schraml P, et al.
Cancers (Basel)
. 2021 May;
13(9).
PMID: 33946379
Intra-tumour heterogeneity is the molecular hallmark of renal cancer, and the molecular tumour composition determines the treatment outcome of renal cancer patients. In renal cancer tumourigenesis, in general, different tumour...
4.
Boettcher S, Wilk C, Singer J, Beier F, Burcklen E, Beisel C, et al.
Blood
. 2020 Mar;
135(18):1548-1559.
PMID: 32181816
Clonal hematopoiesis (CH) is associated with age and an increased risk of myeloid malignancies, cardiovascular risk, and all-cause mortality. We tested for CH in a setting where hematopoietic stem cells...
5.
Szczerba B, Castro-Giner F, Vetter M, Krol I, Gkountela S, Landin J, et al.
Nature
. 2019 Feb;
566(7745):553-557.
PMID: 30728496
A better understanding of the features that define the interaction between cancer cells and immune cells is important for the development of new cancer therapies. However, focus is often given...
6.
Singer J, Kuipers J, Jahn K, Beerenwinkel N
Nat Commun
. 2018 Dec;
9(1):5144.
PMID: 30514897
Reconstructing the evolution of tumors is a key aspect towards the identification of appropriate cancer therapies. The task is challenging because tumors evolve as heterogeneous cell populations. Single-cell sequencing holds...
7.
Singer F, Irmisch A, Toussaint N, Grob L, Singer J, Thurnherr T, et al.
BMC Med Inform Decis Mak
. 2018 Oct;
18(1):89.
PMID: 30373609
Background: Molecular precision oncology is an emerging practice to improve cancer therapy by decreasing the risk of choosing treatments that lack efficacy or cause adverse events. However, the challenges of...
8.
Singer J, Irmisch A, Ruscheweyh H, Singer F, Toussaint N, Levesque M, et al.
Brief Bioinform
. 2017 Dec;
20(3):778-788.
PMID: 29272324
Molecular profiling of tumor biopsies plays an increasingly important role not only in cancer research, but also in the clinical management of cancer patients. Multi-omics approaches hold the promise of...
9.
Singer J, Ruscheweyh H, Hofmann A, Thurnherr T, Singer F, Toussaint N, et al.
Bioinformatics
. 2017 Oct;
34(1):107-108.
PMID: 28968639
Motivation: Next-generation sequencing is now an established method in genomics, and massive amounts of sequencing data are being generated on a regular basis. Analysis of the sequencing data is typically...
10.
Hofmann A, Behr J, Singer J, Kuipers J, Beisel C, Schraml P, et al.
BMC Bioinformatics
. 2017 Jan;
18(1):8.
PMID: 28049408
Background: Next-generation sequencing of matched tumor and normal biopsy pairs has become a technology of paramount importance for precision cancer treatment. Sequencing costs have dropped tremendously, allowing the sequencing of...