Joan Sabalski
Overview
Explore the profile of Joan Sabalski including associated specialties, affiliations and a list of published articles.
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5
Citations
46
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Recent Articles
1.
Letourneau J, Stroke I, Hilbert D, Cole A, Sturzenbecker L, Marinelli B, et al.
Bioorg Med Chem Lett
. 2018 Nov;
28(23-24):3601-3605.
PMID: 30392779
Synthesis and structure-activity relationships (SAR) of a novel series of benzodiazepinedione-based inhibitors of Clostridium difficile toxin B (TcdB) are described. Compounds demonstrating low nanomolar affinity for TcdB, and which possess...
2.
Stroke I, Letourneau J, Miller T, Xu Y, Pechik I, Savoly D, et al.
Antimicrob Agents Chemother
. 2018 Feb;
62(5).
PMID: 29483125
infection (CDI) is the leading cause of hospital-acquired infectious diarrhea, with significant morbidity, mortality, and associated health care costs. The major risk factor for CDI is antimicrobial therapy, which disrupts...
3.
Letourneau J, Stroke I, Hilbert D, Sturzenbecker L, Marinelli B, Quintero J, et al.
Bioorg Med Chem Lett
. 2018 Jan;
28(4):756-761.
PMID: 29331267
The discovery, synthesis and preliminary structure-activity relationship (SAR) of a novel class of inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB) is described. A high throughput screening (HTS) campaign...
4.
Pu J, Kreft A, Aschmies S, Atchison K, Berkowitz J, Caggiano T, et al.
Bioorg Med Chem
. 2009 May;
17(13):4708-17.
PMID: 19443228
gamma-Secretase inhibitors have been shown to reduce the production of beta-amyloid, a component of the plaques that are found in brains of patients with Alzheimer's disease. A novel series of...
5.
Rosenzweig-Lipson S, Zhang J, Mazandarani H, Harrison B, Sabb A, Sabalski J, et al.
Brain Res
. 2006 Jan;
1073-1074:240-51.
PMID: 16430874
WAY-161503 ((4aR)-8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one), a 5-HT(2B/C) receptor agonist, was characterized in vitro using stable Chinese hamster ovary cell lines expressing each of the human 5-HT2 receptors and in vivo in animal models...