Joakim E Swedberg
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Explore the profile of Joakim E Swedberg including associated specialties, affiliations and a list of published articles.
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Citations
556
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Recent Articles
1.
An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human β-Factor XIIa in a Cyclotide Scaffold
Liu W, de Veer S, Huang Y, Sengoku T, Okada C, Ogata K, et al.
J Am Chem Soc
. 2021 Nov;
143(44):18481-18489.
PMID: 34723512
Cyclotides are plant-derived peptides with complex structures shaped by their head-to-tail cyclic backbone and cystine knot core. These structural features underpin the native bioactivities of cyclotides, as well as their...
2.
White A, de Veer S, Wu G, Harvey P, Yap K, King G, et al.
Angew Chem Int Ed Engl
. 2020 Apr;
59(28):11273-11277.
PMID: 32270580
Ruthenium-catalysed azide-alkyne cycloaddition (RuAAC) provides access to 1,5-disubstituted 1,2,3-triazole motifs in peptide engineering applications. However, investigation of this motif as a disulfide mimetic in cyclic peptides has been limited, and...
3.
Yi Li C, Yap K, Swedberg J, Craik D, de Veer S
J Med Chem
. 2019 Dec;
63(2):816-826.
PMID: 31855419
Chymase is a serine protease that is predominantly expressed by mast cells and has key roles in immune defense and the cardiovascular system. This enzyme has also emerged as a...
4.
Tian S, Swedberg J, Yi Li C, Craik D, de Veer S
ACS Med Chem Lett
. 2019 Aug;
10(8):1234-1239.
PMID: 31413811
Neutrophils produce at least four serine proteases that are packaged within azurophilic granules. These enzymes contribute to antimicrobial defense and inflammation but can be destructive if their activities are not...
5.
Jackson M, Yap K, Poth A, Gilding E, Swedberg J, Poon S, et al.
Front Plant Sci
. 2019 Jun;
10:602.
PMID: 31156672
The backbone cyclic and disulfide bridged sunflower trypsin inhibitor-1 (SFTI-1) peptide is a proven effective scaffold for a range of peptide therapeutics. For production at laboratory scale, solid phase peptide...
6.
Riley B, Ilyichova O, de Veer S, Swedberg J, Wilson E, Hoke D, et al.
Biochemistry
. 2019 May;
58(21):2524-2533.
PMID: 31058493
Sunflower trypsin inhibitor (SFTI-1) is a 14 amino acid serine protease inhibitor. The dual antiparallel β-sheet arrangement of SFTI-1 is stabilized by an N-terminal-C-terminal backbone cyclization and a further disulfide...
7.
Yi Li C, de Veer S, White A, Chen X, Harris J, Swedberg J, et al.
J Med Chem
. 2019 Mar;
62(7):3696-3706.
PMID: 30888159
Sunflower trypsin inhibitor-1 (SFTI-1) is a 14-amino acid cyclic peptide that shares an inhibitory loop with a sequence and structure similar to a larger family of serine protease inhibitors, the...
8.
Chen X, Riley B, de Veer S, Hoke D, Van Haeften J, Leahy D, et al.
PLoS One
. 2019 Jan;
14(1):e0210842.
PMID: 30668585
Engagement of an extended β-sheet is a common substrate/inhibitor interaction at the active site of serine proteases and is an important feature of Laskowski mechanism inhibitors that present a substrate-like...
9.
Swedberg J, Ghani H, Harris J, de Veer S, Craik D
ACS Med Chem Lett
. 2019 Jan;
9(12):1258-1262.
PMID: 30613336
Kallikrein-related peptidase 4 (KLK4) is a serine protease that has putative intracellular and extracellular functions in prostate cancer progression. Here we show that MCoTI-II, a 34-amino acid cyclic peptide found...
10.
Swedberg J, Wu G, Mahatmanto T, Durek T, Caradoc-Davies T, Whisstock J, et al.
J Med Chem
. 2018 Dec;
62(2):552-560.
PMID: 30520638
Antifibrinolytic drugs provide important pharmacological interventions to reduce morbidity and mortality from excessive bleeding during surgery and after trauma. Current drugs used for inhibiting the dissolution of fibrin, the main...