Joachim Altschmied
Overview
Explore the profile of Joachim Altschmied including associated specialties, affiliations and a list of published articles.
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54
Citations
1032
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Recent Articles
1.
Jakobs P, Rafflenbeul A, Post W, Ale-Agha N, Gross V, Pick S, et al.
Cells
. 2024 Nov;
13(22).
PMID: 39594576
The most common trigger of sepsis and septic shock is bacterial lipopolysaccharide (LPS). Endothelial cells are among the first to encounter LPS directly. Generally, their function is closely linked to...
2.
Merk D, Cox F, Jakobs P, Promel S, Altschmied J, Haendeler J
Antioxidants (Basel)
. 2024 Apr;
13(4).
PMID: 38671891
The endothelium, the innermost cell layer of blood vessels, is not only a physical barrier between the bloodstream and the surrounding tissues but has also essential functions in vascular homeostasis....
3.
Dietzsch A, Al-Hasani H, Altschmied J, Bottermann K, Brendler J, Haendeler J, et al.
Signal Transduct Target Ther
. 2024 Apr;
9(1):103.
PMID: 38664368
Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide prevalence. Understanding the complex network of food intake and energy balance regulation is an essential prerequisite...
4.
Merk D, Greulich J, Vierkant A, Cox F, Eckermann O, von Ameln F, et al.
Antioxidants (Basel)
. 2023 Jun;
12(6).
PMID: 37371974
The maintenance of Thioredoxin-1 (Trx-1) levels, and thus of cellular redox homeostasis, is vital for endothelial cells (ECs) to prevent senescence induction. One hallmark of EC functionality, their migratory capacity,...
5.
Kleinbongard P, Kuthan P, Eickelmann C, Jakobs P, Altschmied J, Haendeler J, et al.
Int J Cardiol
. 2022 Jun;
363:159-162.
PMID: 35728699
Background: In patients undergoing interventional or surgical coronary revascularization, subclinical hypothyroidism is common and associated with worse outcome, including the need for postoperative inotropic support. In isolated rat hearts with...
6.
Brinkmann V, Romeo M, Larigot L, Hemmers A, Tschage L, Kleinjohann J, et al.
Antioxidants (Basel)
. 2022 Apr;
11(4).
PMID: 35453298
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose activity can be modulated by polyphenols, such as curcumin. AhR and curcumin have evolutionarily conserved effects on aging. Here,...
7.
Cox F, Misiou A, Vierkant A, Ale-Agha N, Grandoch M, Haendeler J, et al.
Cells
. 2022 Feb;
11(3).
PMID: 35159155
Cardiovascular diseases (CVDs) contribute to a large part of worldwide mortality. Similarly, two of the major risk factors for these diseases, aging and obesity, are also global problems. Aging, the...
8.
Milenkovic D, Rodriguez-Mateos A, Lucosz M, Istas G, Declerck K, Sansone R, et al.
Mol Nutr Food Res
. 2022 Jan;
66(21):e2100991.
PMID: 35094491
Scope: While cocoa flavanol (CF) consumption improves cardiovascular risk biomarkers, molecular mechanisms underlying their protective effects are not understood. Objective: To investigate nutri(epi)genomic effects of CF and identify regulatory networks...
9.
Bogorodskiy A, Okhrimenko I, Burkatovskii D, Jakobs P, Maslov I, Gordeliy V, et al.
Cells
. 2021 Dec;
10(12).
PMID: 34944035
Mitochondria play a critical role in providing energy, maintaining cellular metabolism, and regulating cell survival and death. To carry out these crucial functions, mitochondria employ more than 1500 proteins, distributed...
10.
Ale-Agha N, Jakobs P, Goy C, Zurek M, Rosen J, Dyballa-Rukes N, et al.
Circulation
. 2021 Oct;
144(23):1876-1890.
PMID: 34672678
Background: The catalytic subunit of telomerase, telomerase reverse transcriptase (TERT), has protective functions in the cardiovascular system. TERT is not only present in the nucleus but also in mitochondria. However,...