Role of Mitochondrial Protein Import in Age-Related Neurodegenerative and Cardiovascular Diseases

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2021 Dec 24

PMID 34944035

Citations 7

Authors

Andrey Bogorodskiy

Ivan Okhrimenko

Dmitrii Burkatovskii

Philipp Jakobs

Ivan Maslov

Valentin Gordeliy

Norbert A Dencher

Thomas Gensch

Wolfgang Voos

Joachim Altschmied

Judith Haendeler

Valentin Borshchevskiy

Affiliations

Soon will be listed here.

Abstract

Mitochondria play a critical role in providing energy, maintaining cellular metabolism, and regulating cell survival and death. To carry out these crucial functions, mitochondria employ more than 1500 proteins, distributed between two membranes and two aqueous compartments. An extensive network of dedicated proteins is engaged in importing and sorting these nuclear-encoded proteins into their designated mitochondrial compartments. Defects in this fundamental system are related to a variety of pathologies, particularly engaging the most energy-demanding tissues. In this review, we summarize the state-of-the-art knowledge about the mitochondrial protein import machinery and describe the known interrelation of its failure with age-related neurodegenerative and cardiovascular diseases.

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