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Jitendra Kumar Saxena

Explore the profile of Jitendra Kumar Saxena including associated specialties, affiliations and a list of published articles. Areas
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Articles 35
Citations 169
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Recent Articles
1.
Kaushik M, Hoti S, Saxena J, Hingamire T, Shanmugam D, Joshi R, et al.
Acta Parasitol . 2023 Oct; 68(4):832-841. PMID: 37831282
Background: As per estimates by WHO in 2021 almost half of the world's population was at risk of malaria and > 0.6 million deaths were attributed to malaria. Therefore, the...
2.
Yadav S, Gupta S, Saeed M, Mustafa H, Saxena J, Murthy P
Acta Parasitol . 2022 Jan; 67(2):784-793. PMID: 35083711
Purpose: We identified calreticulin in human filaria Brugia malayi (BmCRT) that shares 97% homology with Wuchereria bancrofti calreticulin (WbCRT), but only 56% with human calreticulin. We found that BmCRT binds...
3.
Yadav S, Sharma P, Sharma A, Ganga L, Saxena J, Srivastava M
ACS Infect Dis . 2021 Mar; 7(4):790-799. PMID: 33667079
Lymphatic filariasis causes permanent and long-term disability worldwide. Lack of potent adulticidal drugs, the emergence of drug resistance, and the nonavailability of effective vaccines are the major drawbacks toward LF...
4.
Gaur N, Kumar K, Gupta C, Saxena J
Protein Expr Purif . 2019 Mar; 159:1-9. PMID: 30831225
Arginase catalyzes the first committed step in the biosynthesis of polyamines that enable cell growth and hence potential drug target for the treatment of leishmaniasis. The arginase from Leishmania donovani...
5.
Yadav S, Prakash J, Saxena J
Int J Biol Macromol . 2018 Jun; 117:1157-1168. PMID: 29890245
Calreticulin (CRT), a highly conserved ubiquitous eukaryotic protein with a molecular mass of 46 kDa, containing three domains (N, P, and C) is involved in promoting prolonged parasite-host relations. Brugia...
6.
Verma P, Doharey P, Yadav S, Omer A, Singh P, Saxena J
EXCLI J . 2017 Aug; 16:824-839. PMID: 28827998
Lymphatic filariasis results in an altered lymphatic system and the abnormal enlargement of body parts, causing pain, serious disability and social stigma. Effective vaccines are still not available nowadays, drugs...
7.
Yadav S, Gupta S, Saxena J
Int J Biol Macromol . 2017 Apr; 102:986-995. PMID: 28416397
Calreticulin of Brugia malayi (BmCRT) play very important role in host-parasite interaction. In previous study it was found that BmCRT is responsible for prevention of host classical complement pathway activation...
8.
Kumar R, Doharey P, Saxena J, Rathaur S
Protein Expr Purif . 2017 Feb; 132:152-163. PMID: 28192198
Phosphoglycerate kinase (PGK) is a glycolytic enzyme present in many parasites. It has been reported as a candidate molecule for drug and vaccine developments. In the present study, a full-length...
9.
Doharey P, Singh S, Verma P, Verma A, Rathaur S, Saxena J
Int J Biol Macromol . 2016 Apr; 88:565-71. PMID: 27044348
Lymphatic filariasis is a debilitating disease caused by lymph dwelling nematodal parasites like Wuchereria bancrofti, Brugia malayi and Brugia timori. Thymidylate kinase of B. malayi is a key enzyme in...
10.
Verma A, Chandra S, Suthar M, Doharey P, Siddiqi M, Saxena J
Int J Biol Macromol . 2016 Jan; 85:645-54. PMID: 26763177
Brugia malayi Glucose 6-phosphate dehydrogenase apoenzyme (BmG6PD) was expressed and purified by affinity chromatography to study the differences in kinetic properties of enzyme and the effect of the cofactor NADP(+)...